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Interaction between glutamatergic and dopaminergic tone in the nucleus accumbens of mice: evidence for a dual glutamatergic function with respect to psychomotor control

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Summary

The rotation induced by a unilateral injection of the competitive NMDA receptor antagonist AP-5 was studied in mice with different tone in the central dopaminergic systems. AP-5 induced contralateral rotation in monoamine-depleted mice and in monoamine-depleted mice treated with a dopamine D-1 receptor agonist. In contrast, AP-5 induced predominantly ipsilateral rotation in monoamine-depleted mice treated with a mixed D-1/D-2 or a D-2 selective dopamine agonist and in mice with intact monoaminergic systems.

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  1. A. Svensson

    Present address: Department of Pharmacology, University of Göteborg, Sweden

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  1. Department of Pharmacology, University of Göteborg, Sweden

    M. L. Carlsson & A. Carlsson

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  1. A. Svensson
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  2. M. L. Carlsson
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  3. A. Carlsson
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Svensson, A., Carlsson, M.L. & Carlsson, A. Interaction between glutamatergic and dopaminergic tone in the nucleus accumbens of mice: evidence for a dual glutamatergic function with respect to psychomotor control. J. Neural Transmission 88, 235–240 (1992). https://doi.org/10.1007/BF01244735

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  • DOI: https://doi.org/10.1007/BF01244735

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