Skip to main content
Log in

Effects of subacute exposure to noise on the noradrenergic innervation of the cardiovascular system in young and aged rats: a morphofunctional study

  • Full Papers
  • Published:
Journal of Neural Transmission / General Section JNT Aims and scope Submit manuscript

Summary

The effects of subacute noise stress on the noradrenergic pattern and receptor-mediated responses were examined in aorta and atria of young and aged rats. Noise exposure increased the density of noradrenergic fibres and responses to the β-adrenergic agonist isoprenaline in the cardiac tissue of young animals. In aged rats, the stressing stimulus markedly increased the maximal response to the α-agonist on the aortic musculature; on the contrary, a reduced responsiveness to the β-agonist was observed at the cardiac level, without any noteworthy changes in the noradrenergic pattern in comparison to aged controls. The present results indicate that subacute noise stress induces both morphological and functional modifications of the noradrenergic nervous system and also that after subacute noise stress, morphological changes do not necessarily correspond exactly to functional data; the latter show responses that are more widely differentiated than the morphological ones.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Alario P, Gamallo A, Beato MJ, Trancho G (1987) Body weight gain, food intake and adrenal development in chronic noise stressed rats. Physiol Behav 40: 29–32

    Google Scholar 

  • Ariens EJ, Van Rossum JM (1957) pDx, pAx and slope values in the analysis of pharmacodynamics. Arch Int Pharmacodyn Ther 110: 275–300

    Google Scholar 

  • Beardwood CJ, Mundell CA, Utian WH (1975) Gonadotropin excretion in response to audiostimulation of human subjects. Am J Obstet Gynaecol 121: 682–687

    Google Scholar 

  • Burnstock G (1986) Autonomic neuromuscular junction: current developments and future directions. J Anat 146: 1–30

    Google Scholar 

  • Chernukh AM, Khaisman EB, Gorizontova MP (1984) Morphologic and functional characteristics of adrenergic innervation of microvessels and terminal blood flow in stress. Pathol Fiziol Exp Ter 2: 30–36

    Google Scholar 

  • Del Tacca M, Paparelli A, Breschi MC, Mazzanti L (1980) Noradrenergic innervation of the heart in untreated and Daunomycin-pretreated animals. Histochemistry 65: 187–191

    Google Scholar 

  • Docherty JR (1990) Cardiovascular responses in ageing: a review. Pharmacol Rev 42 (2): 103–125

    Google Scholar 

  • Ehinger B, Falck B, Sporrong B (1966) Adrenergic fibres to the heart and to peripheral vessels. Bibl Anat (Basel) 8: 35–45

    Google Scholar 

  • Falck B, Hillarp NA, Thieme G, Torp A (1962) Fluorescence of catecholamines and related compounds condensed with formaldehyde. J Histochem Cytochem 10: 348–354

    Google Scholar 

  • Follenius M, Brandemberger G, Lecornu C, Simeoni M, Reinhardt B (1980) Plasma catecholamines and pituitary adrenal hormones in response to noise exposure. Eur J App Occup Physiol 43: 253–261

    Google Scholar 

  • Gue M, Fioramonti J, Frexinos J, Alvinerie M, Bueno L (1987) Influence of acoustic stress by noise on gastrointestinal motility in dogs. Dig Dis Sci 32: 1411–1417

    Google Scholar 

  • Kraicer J, Berand G, Lywood DW (1977) Pars intermedia ACTH and MSH contents: effects of adrenalectomy, gonadectomy and a neurotropic (noise) stress. Neuroendocrinology 23: 352–367

    Google Scholar 

  • Lai H, Carino MA (1990) Acute white noise exposure affects the concentration of benzodiazepine receptors in the brain of the rat. Pharmacol Biochem Behav 36: 985–987

    Google Scholar 

  • Lai H, Carino MA, Wen YF (1989) Repeated noise exposure affects muscarinic cholinergic receptors in the rat brain. Brain Res 488: 361–364

    Google Scholar 

  • McCarty R, Kopin IJ (1978) Alterations in plasma catecholamines and behaviour during acute stress in spontaneously hypertensive and Wistar-Kyoto normotensive rats. Life Sci 22: 997–1006

    Google Scholar 

  • Mingazova IV, Shwalev VN (1970) Adrenergic innervation of abdominal aorta and kidney. Arch Anat Gistol Embriol 59: 77–78

    Google Scholar 

  • Patil PN, Fudge K, Jacobowitz D (1972) Steric aspects of adrenergic drugs. XVIII. α-Adrenergic receptors of mammalian aorta. Eur J Pharmacol 19: 79–87

    Google Scholar 

  • Pellegrini A, Soldani P, Breschi MC, Martinotti E, Paparelli A (1990) Adrenergic innervation of the ductus deferens in young and aging rats: a morpho-functional investigation. Acta Histochem 89: 67–74

    Google Scholar 

  • Santer RM (1982) Fluorescence histochemical observations on the adrenergic innervation of the cardiovascular system in the aged rat. Brain Res Bull 9 (1–6): 667–672

    Google Scholar 

  • Vogel WH, Jensh R (1988) Chronic stress and plasma catecholamine and corticosterone levels in male rats. Neurosci Lett 87: 183–188

    Google Scholar 

  • Wanstall JC, O'Donnel SR (1988) Inhibition of norepinephrine contractions by diltiazem on aorta and pulmonary artery from young and aged rats: influence of alpha-adrenoceptor reserve. J Pharmacol Exp Ther 245: 1016–1020

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Paparelli, A., Soldani, P., Breschi, M.C. et al. Effects of subacute exposure to noise on the noradrenergic innervation of the cardiovascular system in young and aged rats: a morphofunctional study. J. Neural Transmission 88, 105–113 (1992). https://doi.org/10.1007/BF01244816

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01244816

Keywords

Navigation