Skip to main content
Log in

Antagonism by 8-OH-DPAT, but not ritanserin, of catalepsy induced by SCH 23390 in the rat

  • Full Papers
  • Published:
Journal of Neural Transmission / General Section JNT Aims and scope Submit manuscript

Summary

In the present experiments, it was shown that the catalepsy induced by the dopamine D1 antagonist SCH 23390 (0.2 mgkg−1 sc), was completely antagonised by the administration of 8-OH-DPAT (0.1 mg kg−1 sc) for the duration of the effect of SCH 23390 (approx. 120 min). Neither the catalepsy induced by raclopride (16 mg kg−1 sc) nor that induced by SCH 23390 (0.2 mg kg−1 sc) could be antagonised by treatment with the 5-HT2 receptor antagonist ritanserin (0.13–2.0 mg kg−1 sc). Administration of SCH 23390 (0.0125–0.2 mg kg−1 sc) produced a significant suppression of avoidance behavior at all doses, and also produced a significant decrease in the number of intertriai crosses. At the higher doses, 0.05 and 0.2 mg kg−1 sc, there were also escape failures. In contrast to the finding in our previous report that raclopride and 8-OH-DPAT in a synergistic manner produce a suppression of conditioned avoidance behavior, no such interaction was found between 8-OH-DPAT (0.1 mg kg−1 sc) and SCH 23390 (6 μg kg−1 sc) in the present study.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Ahlenius S (1991) Pharmacological evaluation of new antipsychotic drugs. In: Willner P (ed) Behavioral models in psychopharmacology. Cambridge University Press, Cambridge, pp 311–330

    Google Scholar 

  • Ahlenius S, Hillegaart V (1986) Involvement of extrapyramidal motor mechanisms in the suppression of locomotor activity by antipsychotic drugs: a comparison between the effects produced by pre- and postsynaptic inhibition of dopaminergic neurotransmission. Pharmacol Biochem Behav 24: 1409–1415

    Google Scholar 

  • Ahlenius, Ericson EL, Högberg K, Wijkström A (1991) Behavioral and biochemical effects of subchronic treatment with raclopride in the rat: tolerance and brain monoamine receptor sensitivity. Pharmacol Toxicol 68: 302–309

    Google Scholar 

  • Baldessarini RJ (1990) Drugs and the treatment of psychiatric disorders. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics. Pergamon Press, New York, pp 383–435

    Google Scholar 

  • Broekkamp CLE, Oosterloo SK, Berendsen HHG, van Delft AML (1988) Effect of metergoline, fenfluramine, and 8-OH-DPAT on catalepsy induced by haloperidol or morphine. Naunyn-Schmiedebergs Arch Pharmacol 338: 191–195

    Google Scholar 

  • Christensen AV, Arnt J, Hyttel J, Larsen J-J, Svendsen O (1984) Pharmacological effects of a specific dopamine D-1 antagonist SCH 23390 in comparison with neuroleptics. Life Sci 34: 1529–1540

    Google Scholar 

  • Clark D, White FJ (1987) D1 dopamine receptor-the search for function: critical evaluation of the D1-D2 dopamine receptor classification and its functional implications. Synapse 1: 347–388

    Google Scholar 

  • Courvoisier S (1956) Pharmacodynamic basis for the use of chlorpromazine in psychiatry. J Clin Exp Psychopathol Q Rev Psychiatr Neurol 17: 25–37

    Google Scholar 

  • Deutch AY, Moghaddam B, Innis RB, Krystal JH, Aghajanian GK, Bunney BS, Charney DS (1991) Mechanisms of action of atypical antipsychotic drugs: implications for novel therapeutic strategies for schizophrenia. Schizophr Res 4: 121–156

    Google Scholar 

  • Hicks PB (1990) The effect of serotonergic agents on haloperidol-induced catalepsy. Life Sci 47: 1609–1615

    Google Scholar 

  • Hillegaart V, Ahlenius S (1987) Effects of raclopride on exploratory locomotor activity, treadmill locomotion, conditioned avoidance behavior and catalepsy in rats: behavioural profile comparisons between raclopride, haloperidol and preclamol. Pharmacol Toxicol 60: 350–354

    Google Scholar 

  • Hillegaart V, Ahlenius S, Fowler ChJ, Magnusson O (1988) Increased duration of dopamine receptor antagonist-induced effects on both behavior and striatal dopamine turnover by repeated testing in rats. Pharmacol Toxicol 63: 114–117

    Google Scholar 

  • Invernizzi RW, Cervo L, Samanin R (1988) 8-hydroxy-2-(di-n-propylamino)tetralin, a selective serotonin1A receptor agonist, blocks haloperidol-induced catalepsy by an action on raphe nuclei medianus and dorsalis. Neuropharmacology 27: 515–518

    Google Scholar 

  • Iorio LC, Barnett A, Leitz FH, Houser VP, Korduba CA (1983) SCH 23390, a potential benzamide antipsychotic with unique interactions on dopaminergic systems. J Pharmacol Exp Ther 226: 462–468

    Google Scholar 

  • Janssen PAJ, Niemegeers CJE, Awouters F, Schellekens KHL, Megens AAHP, Meert TF (1988) Pharmacology of risperidone (R 64766), a new antipsychotic with serotonin-S2 and dopamine-D2 antagonistic properties. J Pharmacol Exp Ther 244: 685–693

    Google Scholar 

  • Juul Povlsen U, Noring U, Lund Laursen A, Korsgaard S, Gerlach J (1986) Effects of serotonergic and anticholinergic drugs in haloperidol-induced dystonia in cebus monkeys. Clin Neuropharmacol 9: 84–90

    Google Scholar 

  • Korsgaard S, Gerlach J, Christensson E (1985) Behavioral aspects of serotonin-dopamine interaction in the monkey. Psychopharmacology 118: 245–252

    Google Scholar 

  • Köhler C, Hall H, Ögren S-O, Gawell L (1985) Specific in vitro and in vivo binding of [3H]-raclopride. A potent substituted benzamide drug with high affinity for dopamine D2 receptors in the rat brain. Biochem Pharmacol 34: 2251–2259

    Google Scholar 

  • Lappalainen J, Hietala J, Koulu M, Syvälahti E (1990) Neurochemical effects of chronic coadministration of ritanserin and haloperidol: comparison with clozapine effects. Eur J Pharmacol 190: 403–407

    Google Scholar 

  • Leysen JE, Gommeren W, Van Gompel P, Wynants J, Janssen PFM, Laduron PM (1985) Receptor-binding properties in vitro and in vivo of ritanserin a very potent and long acting serotonin-S2 antagonist. Mol Pharmacol 27: 600–611

    Google Scholar 

  • Li CC (1964) Introduction to experimental statistics. McGraw-Hill, New York, pp 207–226

    Google Scholar 

  • Liebman JM, Gerhardt SC, Gerber R (1989) Effects of 5-HT1A agonists and 5-HT2 antagonists of haloperidol-induced dyskinesias in squirrel monkeys: no evidence for reciprocal 5-HT-dopamine interaction. Psychopharmacology 97: 456–461

    Google Scholar 

  • McMillen BA (1985) Comparative chronic effects of buspirone or neuroleptics on rat brain dopaminergic neurotransmission. J Neural Transm 64: 1–12

    Google Scholar 

  • McMillen BA, Williams HL (1990) Effects of chronic ipsapirone on rat brain monoaminergic receptors and responses to chronic antipsychotic treatment. Biogenic Amines 7: 569–575

    Google Scholar 

  • McMillen BA, Scott SM, Davanzo EA (1988) Reversal of neuroleptic-induced catalepsy by novel aryl-piperazine anxiolytic drugs. J Pharm Pharmacol 40: 885–887

    Google Scholar 

  • Meltzer HY (1991) Dopaminergic and serotonergic mechanisms in the action of clozapine. In: Tamminga CA, Schultz SC (eds) Advances in Neuropsychiatry and Psychopharmacology, vol. 1 (Schizophrenia Res). Raven Press, New York, pp 333–338

    Google Scholar 

  • Siegel S, Castellan Jr NJ (1988) Nonparametric statistics for the behavioral sciences. McGraw-Hill, New York

    Google Scholar 

  • Tamminga CA, Gerlach J (1987) New neuroleptics and experimental antipsychotics in schizophrenia. In: Meltzer HY (ed) Psychopharmacology: the third generation of progress. Raven Press, New York, pp 1129–1140

    Google Scholar 

  • Verhave T, Owen JE Jr, Robbins EB (1958) Effects of chlorpromazine and secobarbital on avoidance and escape behavior. Arch Int Pharmacol 116: 45–53

    Google Scholar 

  • Wadenberg M-L, Ahlenius S (1988) Suppression of conditioned avoidance by 8-OH-DPAT in the rat. J Neural Transm 74: 195–198

    Google Scholar 

  • Wadenberg M-L, Ahlenius S (1991) Antipsychotic-like profile of combined treatment with raclopride and 8-OH-DPAT in the rat: enhancement of antipsychotic-like effects without catalepsy. J Neural Transm [GenSect] 83: 43–53

    Google Scholar 

  • Wadenberg M-L, Ahlenius S (1991) Effects of raclopride and haloperidol on spontaneous motor activity and on conditioned avoidance behavior in rats. Arzneimittelforschung 41: 692–695

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wadenberg, M.L. Antagonism by 8-OH-DPAT, but not ritanserin, of catalepsy induced by SCH 23390 in the rat. J. Neural Transmission 89, 49–59 (1992). https://doi.org/10.1007/BF01245351

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01245351

Keywords

Navigation