Summary
The sensitivity of hippocampal pyramidal neurons to the depressant action of serotonin was studied in hippocampal slices obtained from rats treated repetitively with clomipramine (10 mg/kg i.p.; 10 days or 4 weeks), with clorgyline (0.3 mg/kg s.c.; 10 days) or with the vehicle. Whereas clorgyline produced a very pronounced subsensitivity to serotonin, a moderate, non-significant reduction in sensitivity was observed with clomipramine. These electrophysiological findings are consistent with previous biochemical studies.
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Anwyl, R.,Rowan, M. J.: Chronic imipramine treatment antagonizes the inhibitory effect of 5-hydroxy-tryptamine in the rat hippocampal slice (Proceed. Brit. Pharm. Society, Galway). Brit. J. Pharm.80, 668 P.
Charney, D. S., Menkes, D. B., Heninger, G. R.: Receptor sensitivity and the mechanism of action of antidepressant treatment. Arch. gen. Psychiat.38, 1160–1180 (1981).
De Montigny, C., Aghajanian, C. K.: Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurons to serotonin. Science202, 1303–1306 (1978).
Menkes, D. B., Aghajanian, G. K., McCall, R. B.: Chronic antidepressant treatment enhances alpha-adrenergic and serotonergic responses in the facial nucleus. Life Sci.27, 45–55 (1980).
Olpe, H. R., Schellenberg, A.: The sensitivity of cortical neurons to serotonin: effect of chronic treatment with antidepressants, serotonin-uptake inhibitors and monoamine-oxidase blocking drugs. J. Neural Transm.51, 233–244 (1981).
Olpe, H. R., Baudry, M., Fagni, L., Lynch, G.: The blocking action of baclofen on excitatory transmission in the rat hippocampal slices. J. Neurosci.6, 698–703 (1982).
Savage, D., Mendels, J., Frazer, A.: Monoamine oxidase inhibitors and serotonin uptake inhibitors: differential effects on [3H]serotonin binding sites in rat brain. J. Pharmacol. Exp. Ther.212, 259–263 (1980).
Segal, M.: Physiological and pharmacological evidence for a serotonergic projection to the hippocampus. Brain Res.94, 115–131 (1975).
Segal, M.: The action of serotonin in the rat hippocampal slice preparation. J. Physiol. (London)303, 423–439 (1980).
Waldmeier, P. C., Felner, A. E., Maître, L.: Long-term effects of selective MAO inhibitors on MAO activity and amine metabolism. In: Monoamine Oxidase Inhibitors — The State of the Art (Youdim, M. B. H., Paykel, E. S., eds.), pp. 87-102. J. Wiley. 1981.
Wirz-Justice, A., Krauchi, K., Lichtsteiner, M., Feer, H.: Is it possible to modify serotonin receptor sensitivity? Life Sci.23, 1249–1254 (1978).
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Olpe, H.R., Schellenberg, A. & Jones, R.S.G. The sensitivity of hippocampal pyramidal neurons to serotoninin vitro: Effect of prolonged treatment with clorgyline or clomipramine. J. Neural Transmission 60, 265–271 (1984). https://doi.org/10.1007/BF01249098
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DOI: https://doi.org/10.1007/BF01249098