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(−)-Deprenyl can induce soluble superoxide dismutase in rat striata

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Summary

(−)-Deprenyl (0.25 or 2mg/kg) or saline was injected daily into male Wistar rats for 3 weeks. The striata were dissected out and soluble and particulate Superoxide dismutase activity measured. (−)-Deprenyl at 2mg/kg induced a significant increase in the soluble but not the particulate form of the enzyme. The possibility that this action contributes to the ability of (−)-deprenyl to retard nigral degeneration in man and prolong life in rats is discussed.

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Clow, A., Hussain, T., Glover, V. et al. (−)-Deprenyl can induce soluble superoxide dismutase in rat striata. J. Neural Transmission 86, 77–80 (1991). https://doi.org/10.1007/BF01250378

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  • DOI: https://doi.org/10.1007/BF01250378

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