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Pergolide can induce soluble Superoxide dismutase in rat striata

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Summary

Pergolide, a dopamine receptor agonist, given daily i.p. for three weeks at 0.04mg/kg and 0.4mg/kg, significantly induced soluble (Cu-Zn) superoxide dismutase in the rat striatum, while having no effect on the mitochondrial (Mn) form of the enzyme. Such induction, which can also be effected by (−)-deprenyl, may help to protect against nigrostriatal degeneration.

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Author notes

  1. A. Clow

    Present address: Division of Biomedical Science, Polytechnic of Central London, UK

Authors and Affiliations

  1. Division of Biomedical Science, Polytechnic of Central London, UK

    T. Hussain

  2. Department of Chemical Pathology, Queen Charlotte's and Chelsea Hospital, UK

    V. Glover & M. Sandler

  3. Department of Pharmacology, King's College, London, UK

    M. Walker & D. Dexter

Authors
  1. A. Clow
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  2. T. Hussain
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  3. V. Glover
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  4. M. Sandler
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  5. M. Walker
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  6. D. Dexter
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Clow, A., Hussain, T., Glover, V. et al. Pergolide can induce soluble Superoxide dismutase in rat striata. J. Neural Transmission 90, 27–31 (1992). https://doi.org/10.1007/BF01250515

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  • DOI: https://doi.org/10.1007/BF01250515

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