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Erythrocyte membrane sodium — potassium adenosine triphosphatase activity in affective disorders

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Summary

Erythrocyte membrane Na+,K+-ATPase activity was studied in drug naive patients with bipolar (BP) mania (n=62) and unipolar (UP) depression (n=60) and normal controls (n=66). Compared to controls there was a significantly decreased Na+,K+-ATPase activity in UP depressives but no change in BP manics. However, lithium treatment caused a significant increase in Na+,K+-ATPase activity although there was no correlation between plasma lithium levels and enzyme activity. Plasma cortisol correlated inversely with Na+,K+-ATPase in UP depressives. Interestingly, the lithium responders [<50% Beck Rafaelson's Mania Rating Scale (BRMS) score] showed a significant increase in Na+,K+-ATPase activity compared to lithium nonresponders (>50% BRMS score). These observations indicate that monitoring of Na+,K+-ATPase activity during lithium therapy is useful to predict a therapeutic response.

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Author notes

  1. P. L. Reddy

    Present address: Department of Pharmacodynamics (M/C 865), College of Pharmacy, University of Illinois, Box 6998, 60680, Chicago, Illinois, USA

Authors and Affiliations

  1. Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore, India

    P. L. Reddy, M. N. Subhash & B. S. Sridhara Rama Rao

  2. Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India

    S. Khanna & S. M. Channabasavanna

Authors
  1. P. L. Reddy
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  2. S. Khanna
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  3. M. N. Subhash
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  4. S. M. Channabasavanna
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  5. B. S. Sridhara Rama Rao
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Reddy, P.L., Khanna, S., Subhash, M.N. et al. Erythrocyte membrane sodium — potassium adenosine triphosphatase activity in affective disorders. J. Neural Transmission 89, 209–218 (1992). https://doi.org/10.1007/BF01250673

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  • DOI: https://doi.org/10.1007/BF01250673

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