Summary
A study of the acute effects of isatin, an endogenous MAO inhibitor related to tribulin, on rat brain serotonergic function was undertaken. A single dose of isatin significantly increased 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations. Synaptosomal 5-HT uptake was unaffected but there was a trend for the number of3H-ketanserin binding sites was to be decreased. The results of the study are discussed in terms of the relationship of isatin to tribulin and their possible causal role in stress.
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McIntyre, I.M., Norman, T.R. Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin. J. Neural Transmission 79, 35–40 (1990). https://doi.org/10.1007/BF01250998
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DOI: https://doi.org/10.1007/BF01250998