Summary
Hypothermic responses to 5-HT1A receptor activation by the selective ligand ipsapirone (IPS) were attenuated in depressed patients as compared to controls. Chronic treatment with amitriptyline (AMI) further impaired 5-HT1Amediated hypothermia. The results indicate a subsensitive (presynaptic) 5-HT1A receptor and/or a defective post-receptor signalling pathway in depression and are consistent with the hypothesis that 5-HT1A receptors are down-regulted during AMI treatment.
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Lesch, K.P., Disselkamp-Tietze, J. & Schmidtke, A. 5-HT1A receptor function in depression: effect of chronic amitriptyline treatment. J. Neural Transmission 80, 157–161 (1990). https://doi.org/10.1007/BF01257081
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DOI: https://doi.org/10.1007/BF01257081