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Effect of serotoninergic drugs on stress-induced hyperthermia (SIH) in mice

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Summary

8-OH-DPAT (2.5–10 mg/kg) and buspirone (10 mg/kg) but not 5,7DHT (200 Μg/mouse), pCPA (75 and 150 mg/kg, three times), ritanserin (0.1 and 0.2 mg/kg), LY 53857 (1.5 and 3 mg/kg), GR 38032 F (0.1–100 Μg/kg), TFMPP (5 and 20 mg/kg) and mCPP (2.5 and 5 mg/kg) antagonized the rise in body temperature that occurs to the last mice removed from their group housing, which was termed as stress-induced hyperthermia (SIH). Ro 15-1788, at a dose which blocked the effect of diazepam on SIH, did not reverse the anxiolytic effect of buspirione. Instead, when cerebral 5-HT content was reduced to 50% by 5,7-DHT-induced lesion, the effect of buspirone on SIH was decreased. TFMPP 5 mg/kg did not shorten significantly the onset of SIH as could have been expected by an anxiogenic drug, while the dose of 20 mg/kg did not modify the pattern of SIH at all. The lower dose of TFMPP evoked a hyperthermic and the higher a hypothermic response.

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Abbreviations

TFMPP:

m-trifluoromethylphenylpiperazine

mCPP:

m-chlorophenylpiperazine

pCPA:

P-chlorophenylalanine

5,7 DHT:

5,7 dihydroxytryptamine

8-OH-DPAT:

8-hydroxy-2-(di-N-propylamino)tetralin

5-HT:

serotonin

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Author notes

  1. A. Lecci

    Present address: Pharmacological Research Department, “A. Menarini” Pharmaceuticals, Firenze

  2. F. Borsini

    Present address: Istituto de Angeli, Via Serio 15, I-20139, Milano

  3. A. Mancinelli & M. A. Stasi

    Present address: SigmaTau, Via Pontina Km 30.400, I-00040, Pomezia, Italy

Authors and Affiliations

  1. Pharmacological Research Department, “A. Menarini” Pharmaceuticals, Firenze

    F. Borsini, G. Volterra & A. Meli

  2. “Menarini Ricerche Sud” Pharmacological Research Department, Pomezia, Italy

    A. Mancinelli, V. D'Aranno & M. A. Stasi

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  1. A. Lecci
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  2. F. Borsini
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  7. A. Meli
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Lecci, A., Borsini, F., Mancinelli, A. et al. Effect of serotoninergic drugs on stress-induced hyperthermia (SIH) in mice. J. Neural Transmission 82, 219–230 (1990). https://doi.org/10.1007/BF01272765

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  • DOI: https://doi.org/10.1007/BF01272765

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