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Gastric emptying of enteric-coated tablets

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Abstract

To evaluate the gastric emptying time of pharmaceutical dosage forms in a clinical setting, a relatively simple dual-radionuclide technique was developed. Placebo tablets of six different combinations of shape and size were labeled with indium-111 DTPA and enteric coated. Six volunteers participated in a single-blind and crossover study. Tablets were given in the morning on a fasting stomach with 6 oz of water containing99mTc pertechnetate and continuously observed with a gamma camera. A scintigraph was obtained each minute. The results suggested that the size, shape, or volume of the tablet used in this study had no significant effect in the rate of gastric emptying. The tablets emptied erratically and unpredictably, depending upon their time of arrival in the stomach in relation to the occurrence of interdigestive myoelectric contractions. The method described is a relatively simple and accurate technique to allow one to follow the gastric emptying of tablets.

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Authors and Affiliations

  1. Division of Nuclear Medicine, Indiana University School of Medicine, and Lilly Laboratories for Clinical Research, Indianapolis, Indiana

    H. M. Park MD, S. M. Chernish MD, B. D. Rosenek MD, R. L. Brunelle, B. Hargrove PhD & H. N. Wellman MD

Authors
  1. H. M. Park MD
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  2. S. M. Chernish MD
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  3. B. D. Rosenek MD
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  4. R. L. Brunelle
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  5. B. Hargrove PhD
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  6. H. N. Wellman MD
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Park, H.M., Chernish, S.M., Rosenek, B.D. et al. Gastric emptying of enteric-coated tablets. Digest Dis Sci 29, 207–212 (1984). https://doi.org/10.1007/BF01296253

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  • DOI: https://doi.org/10.1007/BF01296253

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