Abstract
The involvement of sulfhydryl-containing compounds was investigated in the cytoprotective effect of certain antacids against ethanol-induced gastric mucosal damage in the rat. Not only the protective effect of a sulfhydryl containing compound,N-acetylcysteine, was abolished after pretreatment withN-ethylmaleimid, but also the adaptive cytoprotection induced by 20% ethanol. Pretreatment of the animals with the cyclooxygenase inhibitor indomethacin or with the thiol reagentN-ethylmaleimide significantly diminished the cytoprotection evoked by aluminum hydroxide. However, the protective effect of aluminium hydroxide could only be totally abolished by pretreatment with the combination of indomethacin andN-ethylmaleimide. The present results suggest the additional role of sulfhydryl-containing compounds localized in the gastric mucosa in the cytoprotection induced by a mild irritant or by aluminium hydroxide and aluminium hydroxidecontaining antacids as well.
Similar content being viewed by others
References
Robert A, Nezamis JE, Lancaster C, Hanchar AJ: Cytoprotection by prostaglandins in rats: prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 77:433–443, 1979
Robert A, Lancaster C, Davis JP, Field SO, Nezamis JE: Distinction between antiulcer effect and cytoprotection. Scand J Gastroenterol 19(Suppl 101):69–73, 1984
Hollander D, Tarnawski A, Gergely H, Zipser RD: Sucralfate protection of the gastric mucosa against alcohol-induced injury: A prostaglandin-mediated process? Scand J Gastroenterol 19(Suppl 101):97–102, 1984
Szelenyi I, Postius S, Engler H: Evidence for a functional cytoprotective effect produced by antacids in the rat stomach. Eur J Pharmacol 88:403–406, 1983
Szelenyi I: Functional cytoprotection by certain antacids. Acta Physiol Hung 64:259–268, 1984
Szabo S, Trier JS, Frankel PW: Sulfhydryl compounds may mediate gastric cytoprotection. Science 214:200–202, 1981
Tallarida RJ, Murray RB: Manual of Pharmacologic Calculations with Computer Programs. New York, Springer-Verlag, 1984
Robert A: Cytoprotection by prostaglandins. Gastroenterology 77:761–767, 1979
Chaudhury TK, Robert A: Prevention by mild irritants of gastric necrosis produced in rats by sodium taurocholate. Dig Dis Sci 25:830–836, 1980
Szabo S: Role of sulfhydryls and early vascular lesions in gastric mucosal injury.In Recent Advances in Gastrointestinal Cytoprotection. Gy Mozsik, A Par, A Bertelli (eds). Budapest, Akademiai Kiado, 1984, pp 17–28
Ezer E: Aspirin and indomethacin as PGs synthesis-inhibitors show differing actions on the gastric damage induced by acidified ethanol. Dig Dis Sci 30:374, 1985 (abstract)
Szabo S, Trier JS, Brown A, Schnoor J: Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology 88:228–236, 1985
Szabo S, Trier JS, Brown A, La Rocque M: Protection against aspirin-induced hemorrhagic gastric erosions and vascular injury by coadministration of sulfhydryl dugs. Gastroenterology 88:1604, 1985 (abstract)
Ohya Y, Guth PH: Effect of ethanol on rat gastric microcirculation. Gastroenterology 88:1522, 1985 (abstract)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Szelenyi, I., Brune, K. Possible role of sulfhydryls in mucosal protection induced by aluminum hydroxide. Digest Dis Sci 31, 1207–1210 (1986). https://doi.org/10.1007/BF01296520
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01296520