Summary
Vaccines prepared from 75S particles of FMDV, strain A Cruzeiro, although less potent than 146S particle vaccines, conferred immunity to challenge. Heat and acid degraded 75S particles also conferred significant levels of immunity, whereas degraded 146S particle vaccines were ineffective.
References
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Doel, T.R., Chong, W.K.T. Comparative immunogenicity of 146S, 75S and 12S particles of foot-and-mouth disease virus. Archives of Virology 73, 185–191 (1982). https://doi.org/10.1007/BF01314726
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DOI: https://doi.org/10.1007/BF01314726