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A lipid inhibitor of dengue virus in human colostrum and milk; with a note on the absence of anti-dengue secretory antibody

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Summary

Neutralizing activity against dengue virus types 1–4 was observed in milk samples from 5 non-immune and 29 dengue immune women. Anti-dengue activity in milk and colostrum was found only in the lipid component. The inhibitory activity is directed against the virus and not cell surfaces. When immunoglobulin types IgM, IgA, IgG were isolated from colostrum from dengue immune women, no antibody activity was found. Anti-dengue activity in human milk did not decrease over a period of ten months after delivery.

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References

  1. Halstead, S. B., andP. Simasthien: Observations related to the pathogenesis of dengue hemorrhagic fever. II. Antigenic and biologic properties of dengue viruses and their association with disease response in the host. Yale J. Biol. Med.42, 276–292 (1970).

    Google Scholar 

  2. Halstead, S. B., S. Udomsakdi, P. Simasthien, P. Singhara, P. Sukhavachana, andA. Nisalak: Observations related to pathogenesis of dengue hemorrhagic fever. I. Experience with classification of dengue viruses. Yale J. Biol. Med.42, 261–275 (1970).

    Google Scholar 

  3. Marchette, N. J., S. B. Halstead, W. A. Falkler, Jr., A. Stenhouse, andD. Nash: Studies on the pathogenesis of dengue infection in monkeys. III. Sequential distribution of virus in primary and heterologous infections. J. infect. Dis.128, 23–30 (1973).

    Google Scholar 

  4. Michael, J. G., R. Ringenback, andS. Hottenstein: The antimicrobial activity of human colostral antibody in the newborn. J. infect. Dis.124, 445–448 (1971).

    Google Scholar 

  5. Pinter, M.: Antibodies to the Lansing strain of poliomyelitis virus in sera and colostra in Hungary. Acta med. Acad. Sci. hung.4, 105–110 (1953).

    Google Scholar 

  6. Russell, P. K., A. Intavivat, andS. Kanchanapilant: Antidengue immunoglobulins and serum B1 c/a globulin levels in dengue shock syndrome. J. Immunol.102, 412–420 (1969).

    Google Scholar 

  7. Sabin, A. B.: Antipoliomyelitic substance in milk of human beings and certain cows. Amer. J. Dis. Child.80, 866–867 (1950).

    Google Scholar 

  8. Sabin, A. B.: Paralytic consequences of poliomyelitis infection in different parts of world and in different population groups. Amer. J. publ. Hlth.41, 1215–1230 (1951).

    Google Scholar 

  9. Sabin, A. B.: Relationships between arthropod-borne viruses based on antigenic analysis, growth requirements, and selective biochemical inactivation. N. Y. Acad. Sci.56, 580–582 (1953).

    Google Scholar 

  10. Sabin, A. B., andA. H. Fieldsteel: Antipoliomyelitis activity of human and bovine colostrum and milk. Pediatrics.29, 105–115 (1962).

    Google Scholar 

  11. Weiss, F.: Untersuchungen über die Anwesenheit virulizider Vakzineantikörper in der Frauenmilch und über die Frage ihrer trophogenen Übertragung. Ann. paediat. (Basel)152, 193–209 (1939).

    Google Scholar 

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Authors and Affiliations

  1. Department of Tropical Medicine and Medical Microbiology, University of Hawaii School of Medicine, Honolulu, Hawaii

    W. A. Falkler Jr., A. R. Diwan & S. B. Halstead

  2. Department of Microbiology, University of Maryland School of Dentistry, 21201, Baltimore, MD, USA

    W. A. Falkler Jr.

Authors
  1. W. A. Falkler Jr.
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  2. A. R. Diwan
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  3. S. B. Halstead
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With 1 Figure

This investigation was supported by the U.S. Army Medical Research & Development Command, under research contract number DA-17-69-C-9174.

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Falkler, W.A., Diwan, A.R. & Halstead, S.B. A lipid inhibitor of dengue virus in human colostrum and milk; with a note on the absence of anti-dengue secretory antibody. Archives of Virology 47, 3–10 (1975). https://doi.org/10.1007/BF01315587

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  • DOI: https://doi.org/10.1007/BF01315587

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