Summary
Microdosimetry is a branch of radiological physics that provides quantitative characterization of the non-uniformity of energy deposition in uniformly irradiated matter.
Considerations based on microdosimetry indicate that the action of ionizing radiation on the cells of higher organisms depends on the square of the specific energy absorbed in subcellular volumes. This is the basis of the Theory of Dual Radiation Action. The basic postulate of this theory is reviewed and four factors are discussed that modify its elementary formulation.
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Barendsen, G. W.: In: Theoretical and Experimental Biophysics, Vol. 1, 167. Cole, A. (ed.). New York: Marcel Dekker 1967
Bateman, J. L., Johnson, H. A., Bond, V. P., Rossi, H. H.: The dependence on the energy of fast neutrons for spermatogonia depletion in mice. Radiat. Res.35, 86–101 (1968)
Bateman, J. L., Rossi, H. H., Kellerer, A. M., Robinson, C. V., Bond, V. P.: Dose-dependence of fast neutron RBE for lens opacification in mice. Radiat. Res.51, 381–390 (1972)
Dewey, W. C., Noel, J. S., Dettor, C. M.: Changes in radiosensitivity and dispersion of chromatin during the cell cycle of synchronous Chinese hamster cells. Radiat. Res.52, 373–394 (1972)
Kellerer, A. M., Brenot, J.: Nonparametric determination of modifying factors in radiation action. Radiat. Res.56, 28–39 (1973)
Kellerer, A. M., Chmelevsky, D.: Concepts of microdosimetry. III. Mean values of the microdosimetric distributions. Rad. and Environm. Biophys.12, 321–335 (1975)
Kellerer, A. M., Hall, E. J., Rossi, H. H., Teedla, P.: RBE as a function of neutron energy. II. Statistical analysis. Radiat. Res.65, 172–186 (1976)
Kellerer, A. M., Rossi, H. H.: A generalized formulation of dual radiation action. Radiat. Res.75, 471–488 (1978)
Kellerer, A. M., Rossi, H. H.: The Theory of Dual Radiation Action. Current Topics in Radiat. Res. Quart.8, 85–158 (1972)
Miller, R. C., Hall, E. J.: Personal communication 1978
Rossi, H. H.: Specification of radiation quality. Radiat. Res.10, 522–531 (1959)
Rossi, H. H., Bird, R., Colvett, R. D., Kellerer, A. M., Rohrig, N., Lam, Y. M. P.: The molecular ion experiment. Proc. 6th Int. Symp. on Microdosimetry, Brussels, Euratom. Booz, J., Ebert, H. (eds.), p. 937–947, June 1978
Rossi, H. H., Kellerer, A. M.: Biological implications of microdosimetry: I. Temporal aspects. Proc. Fourth Symp. on Microdosimetry, Verbania, Italy 315–330 (1973)
Rossi, H. H., Kellerer, A. M.: Radiation carcinogenesis at low doses. Science175, 200–202 (1972)
Shellabarger, C. J., Brown, R. D., Rao, A. R., Shanley, J. P., Bond, V. P., Kellerer, A. M., Rossi, H. H., Goodman, L. J., Mills, R. E.: Rat mammary carcinogenesis following neutron or x-irradiation. Symp. on the Effects of Neutron Irradiation upon Cell Function, Munich 1973. In ‘Biological Effects of Neutron Irradiation,’ IAEA-SM-179/28, 405–416, 1974
Todd, P. W.: Reversible and irreversible effects of ionizing radiations on the reproductive integrity of mammalian cells cultured in vitro. Thesis University of California, Lawrence Rad. Lab. UCRL 11614, 1964
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Rossi, H.H. The role of microdosimetry in radiobiology. Radiat Environ Biophys 17, 29–40 (1979). https://doi.org/10.1007/BF01323118
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DOI: https://doi.org/10.1007/BF01323118