Skip to main content
Log in

The role of microdosimetry in radiobiology

  • Published:
Radiation and Environmental Biophysics Aims and scope Submit manuscript

Summary

Microdosimetry is a branch of radiological physics that provides quantitative characterization of the non-uniformity of energy deposition in uniformly irradiated matter.

Considerations based on microdosimetry indicate that the action of ionizing radiation on the cells of higher organisms depends on the square of the specific energy absorbed in subcellular volumes. This is the basis of the Theory of Dual Radiation Action. The basic postulate of this theory is reviewed and four factors are discussed that modify its elementary formulation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Barendsen, G. W.: In: Theoretical and Experimental Biophysics, Vol. 1, 167. Cole, A. (ed.). New York: Marcel Dekker 1967

    Google Scholar 

  • Bateman, J. L., Johnson, H. A., Bond, V. P., Rossi, H. H.: The dependence on the energy of fast neutrons for spermatogonia depletion in mice. Radiat. Res.35, 86–101 (1968)

    Google Scholar 

  • Bateman, J. L., Rossi, H. H., Kellerer, A. M., Robinson, C. V., Bond, V. P.: Dose-dependence of fast neutron RBE for lens opacification in mice. Radiat. Res.51, 381–390 (1972)

    Google Scholar 

  • Dewey, W. C., Noel, J. S., Dettor, C. M.: Changes in radiosensitivity and dispersion of chromatin during the cell cycle of synchronous Chinese hamster cells. Radiat. Res.52, 373–394 (1972)

    Google Scholar 

  • Kellerer, A. M., Brenot, J.: Nonparametric determination of modifying factors in radiation action. Radiat. Res.56, 28–39 (1973)

    Google Scholar 

  • Kellerer, A. M., Chmelevsky, D.: Concepts of microdosimetry. III. Mean values of the microdosimetric distributions. Rad. and Environm. Biophys.12, 321–335 (1975)

    Google Scholar 

  • Kellerer, A. M., Hall, E. J., Rossi, H. H., Teedla, P.: RBE as a function of neutron energy. II. Statistical analysis. Radiat. Res.65, 172–186 (1976)

    Google Scholar 

  • Kellerer, A. M., Rossi, H. H.: A generalized formulation of dual radiation action. Radiat. Res.75, 471–488 (1978)

    Google Scholar 

  • Kellerer, A. M., Rossi, H. H.: The Theory of Dual Radiation Action. Current Topics in Radiat. Res. Quart.8, 85–158 (1972)

    Google Scholar 

  • Miller, R. C., Hall, E. J.: Personal communication 1978

  • Rossi, H. H.: Specification of radiation quality. Radiat. Res.10, 522–531 (1959)

    Google Scholar 

  • Rossi, H. H., Bird, R., Colvett, R. D., Kellerer, A. M., Rohrig, N., Lam, Y. M. P.: The molecular ion experiment. Proc. 6th Int. Symp. on Microdosimetry, Brussels, Euratom. Booz, J., Ebert, H. (eds.), p. 937–947, June 1978

    Google Scholar 

  • Rossi, H. H., Kellerer, A. M.: Biological implications of microdosimetry: I. Temporal aspects. Proc. Fourth Symp. on Microdosimetry, Verbania, Italy 315–330 (1973)

  • Rossi, H. H., Kellerer, A. M.: Radiation carcinogenesis at low doses. Science175, 200–202 (1972)

    Google Scholar 

  • Shellabarger, C. J., Brown, R. D., Rao, A. R., Shanley, J. P., Bond, V. P., Kellerer, A. M., Rossi, H. H., Goodman, L. J., Mills, R. E.: Rat mammary carcinogenesis following neutron or x-irradiation. Symp. on the Effects of Neutron Irradiation upon Cell Function, Munich 1973. In ‘Biological Effects of Neutron Irradiation,’ IAEA-SM-179/28, 405–416, 1974

  • Todd, P. W.: Reversible and irreversible effects of ionizing radiations on the reproductive integrity of mammalian cells cultured in vitro. Thesis University of California, Lawrence Rad. Lab. UCRL 11614, 1964

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rossi, H.H. The role of microdosimetry in radiobiology. Radiat Environ Biophys 17, 29–40 (1979). https://doi.org/10.1007/BF01323118

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01323118

Keywords

Navigation