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Effect of 6-hydroxydopamine on oxidative phosphorylation and on monoamine oxidase activity

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Summary

In rat liver homogenates, 6-hydroxydopamine was as potent as 2,4-dinitrophenol in uncoupling oxidative phosphorylation. In a concentration which caused complete uncoupling of oxidative phosphorylation, 6-hydroxydopamine failed to affect the monoamine oxidase activity of rat liver homogenates; the enzyme activity was determined with tyramine as substrate. The results indicate that 6-hydroxydopamine has an effect on oxidative phosphorylation which is not entirely nonspecific. It is possible that this effect is involved in the degeneration of adrenergio nerve endings seen after 6-hydroxydopamine.

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Authors and Affiliations

  1. Institut für Pharmakologie und Toxikologie der Universität Würzburg, Germany

    K. Wagner & U. Trendelenburg

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  1. K. Wagner
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  2. U. Trendelenburg
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This study was supported by the Deutsche Forschungsgemeinschaft.

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Wagner, K., Trendelenburg, U. Effect of 6-hydroxydopamine on oxidative phosphorylation and on monoamine oxidase activity. Naunyn-Schmiedebergs Arch. Pharmak. 269, 112–116 (1971). https://doi.org/10.1007/BF01422020

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  • DOI: https://doi.org/10.1007/BF01422020

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