Abstract
Seven subjects were given one day's treatment with full doses of either aspirin, ibuprofen, or placebo, and then their stomachs were washed out three times at intervals of 10 min, for five successive days. The blood in the recoveries was estimated chemically. After compensating for gastric emptying, the rate of bleeding was expressed as ml blood per day. Relative to placebo, one day's treatment with aspirin increased the rate of blood loss significantly at day 1, median 2.7 ml/day, and not thereafter. A corresponding dose of ibuprofen did not produce any significant bleeding. The procedure gives specific information about gastric bleeding. It can measure rates of bleeding down to 0.01 ml/day.
Similar content being viewed by others
References
Douthwaite AH, Lintott GAM: Gastroscopic observation of the effect of aspirin and certain other substances on the stomach. Lancet 2:1222–1225, 1938
Stubbe LTF, Pietersen JH, Van Heulen C: Aspirin preparations and their noxious effect on the gastrointestinal tract. Br Med J 1:675–680, 1962
Schmid FR, Culic DD: Anti-inflammatory drugs and gastrointestinal bleeding: A comparison of aspirin and ibuprofen. J Clin Pharmacol 16:418–425, 1976
Fisher MA, Hunt JN: A sensitive method for measuring haemoglobin in gastric contents. Digestion 14:409–414 1975
Ivey KJ, Schedl HP: Gastric non-absorbable indicators for studies in man. Gastroenterology 59:234–239, 1970
Colquhoun D: Lectures on Biostatistics. Oxford, Clarendon Press, 1971
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hunt, J.N. A procedure for measuring gastric bleeding caused by drugs. Digest Dis Sci 24, 525–528 (1979). https://doi.org/10.1007/BF01489320
Issue Date:
DOI: https://doi.org/10.1007/BF01489320