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Expression of the receptor for epidermal growth factor correlates with increased dosage of chromosome 7 in malignant melanoma

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Somatic Cell and Molecular Genetics

Abstract

Epidermal growth factor (EGF) receptor is expressed selectively by human melanoma cells which show the presence of an extra copy of chromosome 7. None of the cells of benign pigmented lesions (nevi) or radial growth phase (nonmetastatic) primary melanoma expressed EGF receptor and none of these cells showed an extra copy of chromosome 7. The results indicate that a single extra dose of a gene (for EGF receptor) may provide a selective advantage to cells in the late stages of tumorigenesis.

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Authors and Affiliations

  1. The Wistar Institute of Anatomy and Biology, 19104, Philadelphia, Pennsylvania

    Hilary Koprowski, Meenhard Herlyn & Alonzo Ross

  2. Department of Human Genetics, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania

    Gloria Balaban & Annette Parmiter

  3. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 19104, Philadelphia, Pennsylvania

    Peter Nowell

Authors
  1. Hilary Koprowski
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  2. Meenhard Herlyn
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  3. Gloria Balaban
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  4. Annette Parmiter
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  5. Alonzo Ross
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  6. Peter Nowell
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Koprowski, H., Herlyn, M., Balaban, G. et al. Expression of the receptor for epidermal growth factor correlates with increased dosage of chromosome 7 in malignant melanoma. Somat Cell Mol Genet 11, 297–302 (1985). https://doi.org/10.1007/BF01534687

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  • DOI: https://doi.org/10.1007/BF01534687

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