Abstract
Low-molecular-weight Ia antigens can be detected in mouse serum. A procedure for isolating these antigens from serum in high yield is described. The Ia antigen preparation was found to be rich in carbohydrate, low in protein, and strongly bound to Concanavalin A andLotus lectins. Furthermore, the Ia antigenicity was destroyed by periodate oxidation and neuraminidase treatment, but was unaffected by pronase. These observations strongly suggest that the Ia antigens in serum are oligosaccharide in nature. Such a conclusion implies that at least some of the genes in theI region of theH-2 gene complex code for glycosyl transferase enzymes.
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Parish, C.R., Jackson, D.C. & McKenzie, I.F.C. Low-molecular-weight Ia antigens in normal mouse serum. Immunogenetics 3, 455–463 (1976). https://doi.org/10.1007/BF01576974
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DOI: https://doi.org/10.1007/BF01576974