Skip to main content
SpringerLink
Log in

International experiences with ofloxacin, a new quinolone

Internationale Erfahrungen mit Ofloxacin, einem neuen Chinolon

  • Opening Remarks
  • Published:
Infection Aims and scope Submit manuscript

Summary

In vitro andin vivo antibacterial activities of ofloxacin, a new quinolone, are presented. Ofloxacin was found to be characterized by potent bactericidal activity due to its strong inhibition of bacterial DNA gyrase. The high antibacterial activity of ofloxacinin vivo was discussed with respect to its physicochemical properties, i.e., hydrophobicity and bioavailability including high serum concentrations and easy entry into bacterial cells.

Zusammenfassung

Daten vonIn-vitro-undIn-vivo-Studien zur antibakteriellen Wirksamkeit von Ofloxacin, einem neuen Chinolon, werden vorgestellt. Ofloxacin zeichnet sich durch hohe bakterizide Aktivität infolge starker inhibitorischer Wirkung gegen die bakterielle DNA-Gyrase aus. Die hohe antibakterielle Wirksamkeit von Ofloxacinin vivo wird im Zusammenhang mit seinen physikochemischen Eigenschaften, d. h. Hydrophobizität und Bioverfügbarkeit, einschließlich der hohen Serumkonzentrationen und der ausgeprägten Fähigkeit von Ofloxacin, in bakterielle Zellen einzudringen, diskutiert.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literature

  1. Hayakawa, T., Hiramitsu, T., Imamura, M., Ebata, T., Kanaya, N., Atarashi, S., Yokohama, S., Furukawa, M., Tanaka, Y.: Structureactivity relationships of quinolone antibacterial agents including ofloxacin. In:Mitsuhashi, S., Daikos, K. (eds.): Ofloxacin: a new quinolone antibacterial agent. Proceedings of the 14th International Congress of Chemotherapy Kyoto, University of Tokyo Press, Tokyo, 1986 pp. 27–31.

  2. Gellert, M., Mizuuchi, K., O'Dea, M. H., Itoh, T., Tomizawa, J. Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity. Proc. Natl. Acad. Sci. U.S.A. 74 (1977) 4772–4776.

    Google Scholar 

  3. Sato, K., Inoue, Y., Yamashita, S., Inoue, M., Mitsuhashi, S.: Inhibitory effects of ofloxacin and other new pyridone-carboxylic acids on the activities of DNA gyrases isolated fromE. coli, P. aeruginosa andB. fragilis. In:Mitsuhashi, S., Daikos, K. (eds.): Ofloxacin: a new quinolone antibacterial agent. Proceedings of the 14th International Congress of Chemotherapy Kyoto, University of Tokyo Press, Tokyo, 1986 pp. 21–25.

  4. Hirai, K., Aoyama, H., Irikura, T., Iyobe, S., Mitsuhashi, S. Differences in susceptibility to quinolones of outer membrane mutants ofSalmonella typhimurium andEscherichia coli. Antimicrob. Agents Chemother. 29 (1986) 535–538.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Gunma University School of Medicine, Showa-machi, Maebashi City, Gunma, Japan

    S. Mitsuhashi M. D.

Authors
  1. S. Mitsuhashi M. D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mitsuhashi, S. International experiences with ofloxacin, a new quinolone. Infection 14 (Suppl 4), S223–S225 (1986). https://doi.org/10.1007/BF01661276

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01661276

Keywords

Search

Navigation