Summary
Iron status was assessed by measuring serum (S-) ferritin and hemoglobin (Hb) in a population survey comprising 1359 nonpregnant Danish women, in age cohorts of 30,40, 50, and 60 years; 809 were premenopausal and 550 postmenopausal. Median age for menarche was 14 years, for menopause (artificial and natural) 48 years. Premenopausal women had lower S-ferritin (median 37Μg/l) than postmenopausal women (median 71Μg/l;p<0.0001). Of the premenopausal women, 17.7% had S-ferritin < 15Μg/l (i.e., depleted iron stores), and 23.1% S-ferritin of 15–30Μg/l (i.e., small iron stores). Corresponding figures in postmenopausal women were 3.3% and 10.3%. Hb values in premenopausal women were mean 137±10 (SD) g/l (8.5±0.6 mmol/l) vs. 140±10 g/l (8.7±0.6 mmol/l) in postmenopausal women (p<0.0001); 4.1% of pre- and 3.3% of postmenopausal women had values < 121 g/l (7.5 mmol/l). Iron deficiency anemia (i.e., S-ferritin < 15Μg/l and Hb < 121 g/l) was found in 2.6% of pre- and 0.36% of postmenopausal women. Premenopausal multipara had lower S-ferritin than nulli- and unipara (p<0.04). The use of oral contraceptives had a marked influence on iron stores; premenopausal women taking the pill had higher S-ferritin and a lower frequency of depleted iron reserves than nonusers (p<0.01). Postmenopausal estrogen treatment had no influence on S-ferritin or Hb.
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References
Beaton GH (1974) Epidemiology of iron deficiency. In: Jacobs A, Worwood M (eds) Iron in biochemistry and medicine. Academic, London, pp 477–528
Boldsen J, Jeune B (1990) Distribution of age at menopause in two Danish samples. Hum Biol 62: 291–300
Cole SK, Billewicz WZ, Thomson AM (1971) Sources of variation in menstrual blood loss. J Obstet Gynaecol Br Commonw 78: 933–939
Danmarks Statistik (1985) Statistical yearbook 89: 35
Dukes PP, Goldwasser E (1961) Inhibition of erythropoiesis by estrogens. Endocrinology 69: 21–29
Frasinelli-Gunderson EP, Margen S, Brown JR (1985) Iron stores in users of oral contraceptive agents. Am J Clin Nutr 41: 703–712
Gillebaud J, Bonner J, Morehead J, Matthews A (1976) Menstrual blood loss with intrauterine devices. Lancet 1: 387–390
Green R, Charlton R, Seftel H, Bothwell T, Mayet F, Adams B, Finch CA, Layrisse M (1968) Body iron excretion in man. A collaborative study. Am J Med 45: 336–353
Hagerup L, Eriksen M, Schroll M, Hollnagel H, Agner E, Larsen S (1981) The Glostrup Population Studies collection of epidemiological tables. Scand J Soc M [Suppl 20]
Hallberg L (1981) Iron nutrition in women in industrialized countries. Bibl Nutr Dieta 30: 111–123
Hallberg L, Högdahl AM, Nilsson L, Rybo G (1966) Menstrual blood loss — a population study. Variation at different ages and attempts to define normality. Acta Obstet Gynecol Scand 45: 320–351
Heinrich HC, Oppitz KH, Busch H (1973) Eisenmangel und Eisenprophylaxe bei Blutspendern. Klin Wochenschr 51: 107–117
JØrgensen LM, Kirchhoff M, Schultz-Larsen K, Schroll M (1992) Food and nutrient intake in Denmark estimated by 7-day food records. III. Intake of vitamins, minerals and trace elements. Scand J Nutr 36: 8–11
Meeks GR, Gookin K, Morrison JC (1987) Iron deficiency inpregnancy. In: Kitay DZ (ed) Hematologic problems in pregnancy. Medical Economics, Oradell, NJ, pp 27–47
Milman N, Ibsen KK (1984) Serum ferritin in healthy Danish children and adolescents. Scand J Haematol 33: 260–266
Milman N, Kirchhoff M (1991) The influence of blood donation on iron stores assessed by serum ferritin and hemoglobin in a population survey of 1359 Danish women. Ann Hematol 63: 27–32
Milman N, Kirchhoff M (1991) Iron stores in 1433, 30- to 60-year-old Danish males. Evaluation by serum ferritin and haemoglobin. Scand J Clin Lab Invest 51: 635–641
Milman N, Kirchhoff M (1992) Iron stores in 1359, 30- to 60-year-old Danish women: evaluation by serum ferritin and hemoglobin. Ann Hematol 64: 22–27
Milman N, Ibsen KK, Christensen JM (1987) Serum ferritin and iron status in mothers and newborn infants. Acta Obstet Gynecol Scand 66: 205–211
Milman N, Ingerslev J, Graudal N (1990) Serum ferritin and iron status in a population of “healthy” 85-year-old individuals. Scand J Clin Lab Invest 50: 77–83
Milman N, Jensen KH, Jargensen T, Lyhne N, Rosdahl N (1992) Iron status in 883, 35- to 65-year-old Danish women. Relation to menstruation and methods of contraception. Acta Obstet Gynecol Scand (submitted for publication)
Milman N, Pedersen NS, Visfeldt J (1983) Serum ferritin in healthy Danes: relation to bone marrow haemosiderin iron. Dan Med Bull 30: 115–120
Nilsson L, Sölvell L (1967) Clinical studies on oral contraceptives — a randomized, double-blind crossover study of four different populations. Acta Obstet Gynecol Scand 46: [Suppl 8]
Pilch SM, Senti FR (eds) (1984) Assessment of the iron nutritional status of the US population based on data collected in the second National Health and Nutrition Examination survey, 1976–1980. Prepared for the Food and Drug Administration under Contract no FDA 223-83-2384, Bethesda, Maryland: Life Sciences Research Office, Federation of American Societies for Experimental Biology
Riphagen FE, Lehert P (1989) A survey of contraception in five West European countries. J Biosoc Sci 21: 23–46
Wielandt H, Boldsen J (1989) Relationship between biological and social aspects of sexual maturity among young Danes. Biol Soc 6: 55–60
World Health Organization (1972) Nutritional anaemias. Tech Rep Ser 503
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Milman, N., Kirchhoff, M. & JØrgensen, T. Iron status markers, serum ferritin and hemoglobin in 1359 Danish women in relation to menstruation, hormonal contraception, parity, and postmenopausal hormone treatment. Ann Hematol 65, 96–102 (1992). https://doi.org/10.1007/BF01698138
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DOI: https://doi.org/10.1007/BF01698138