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The BFM-protocol for HIV-negative Burkitt's lymphomas and L3 ALL in adult patients: a high chance for cure

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Summary

During a period of 9 years we used the pediatric BFM-NHL protocol for treatment of 14 adult patients with Burkitt's lymphoma or L3 acute lymphoblastic leukemia. Ten of 14 patients obtained a complete remission including 5/8 with stage-IV disease or B-ALL. After a median follow-up of 55 months none of these ten patients relapsed. The projected survival after 8 years is 71%. Toxicity was moderate, with one early death; a tumor lysis syndrome occurred in four patients. From our experience we conclude that the BFM-NHL protocol is very effective in adult patients, with a high cure rate and acceptable toxicity, even in advanced stages of disease.

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Authors and Affiliations

  1. Medizinische Klinik und Poliklinik, Innere Medizin I, Universität des Saarlandes, W-6650, Homburg/Saar, Germany

    H. W. Pees, H. Radtke & J. Schwamborn

  2. Klinik für Kinder- und Jugendmedizin, Universität des Saarlandes, W-6650, Homburg/Saar, Germany

    N. Graf

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  1. H. W. Pees
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  2. H. Radtke
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  3. J. Schwamborn
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  4. N. Graf
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Pees, H.W., Radtke, H., Schwamborn, J. et al. The BFM-protocol for HIV-negative Burkitt's lymphomas and L3 ALL in adult patients: a high chance for cure. Ann Hematol 65, 201–205 (1992). https://doi.org/10.1007/BF01703945

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  • DOI: https://doi.org/10.1007/BF01703945

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