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In vitro activity of quinupristin/dalfopristin and newer quinolones combined with gentamicin against resistant isolates ofEnterococcus faecalis andEnterococcus faecium

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Abstract

In a study designed to obtain data on compounds active against enterococci, the minimum inhibitory concentrations (MICs) of quinupristin/dalfopristin (RP 59500) and the novel quinolones DU-6859a, trovafloxacin, levofloxacin, and sparfloxacin were determined for 122Enterococcus faecalis and sevenEnterococcus faecium isolates. In addition, 15Enterococcus faecalis isolates resistant to gentamicin, DU-6859a, and trovafloxacin were exposed over time to combinations of DU-6859a plus gentamicin and trovafloxacin plus gentamicin. DU-6859a and trovafloxacin were found to be the most active compounds againstEnterococcus faecalis and DU-6859a and RP 59500 againstEnterococcus faecium. Synergy between either DU-6859a or trovafloxacin and gentamicin was observed with 27 to 35% of the isolates. It is concluded that DU-6859a and trovafloxacin are very potent against enterococci, especially when combined with gentamicin.

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Authors and Affiliations

  1. 1st Department of Propaedeutic Medicine, Athens Medical School, Laiko General Hospital, 17 Aghiou Thoma Street, 11527, Athens, Greece

    E. J. Giamarellos-Bourboulis, P. Grecka & H. Giamarellou

  2. Department of Special Infections, Athens General Hospital “G. Gennimatas”, Athens, Greece

    H. Sambatakou

Authors
  1. E. J. Giamarellos-Bourboulis
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  2. H. Sambatakou
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  3. P. Grecka
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  4. H. Giamarellou
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Giamarellos-Bourboulis, E.J., Sambatakou, H., Grecka, P. et al. In vitro activity of quinupristin/dalfopristin and newer quinolones combined with gentamicin against resistant isolates ofEnterococcus faecalis andEnterococcus faecium . Eur. J. Clin. Microbiol. Infect. Dis. 17, 657–661 (1998). https://doi.org/10.1007/BF01708351

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