Summary
In 21 patients with essential hypertension the effects of moderate sodium restriction from the usual 200 mmol Na/day to 80 mmol/day over 4 weeks were compared with the effects of a combined low-sodium/high-potassium intake (80 mmol Na/120 mmol K) which was also given over 4 weeks in an open crossover trial. Systolic blood pressure in nine untreated patients with essential hypertension decreased significantly by between 5 and 7 mm Hg during moderate sodium restriction; no further decrease of blood pressure occurred during the combined low-sodium/high-potassium diet. In 12 treated patients with essential hypertension moderate sodium restriction or the combined low-sodium/high-potassium diet enabled a marked reduction of anti-hypertensive therapy in eight patients without impairment of blood pressure control (β-blockers by an average of 32%, saluretics by an average of 27% and vasodilators by an average of 24%). Here there were also no substantial differences between low-sodium intake and the combined low-sodium/high-potassium intake. It is concluded that sodium restriction to 80 mmol/day is effective in lowering systolic blood pressure but that a combined low-sodium/high-potassium diet does not further improve blood pressure control if the usual potassium intake is at least 80 mmol/day. Considerable reduction of anti-hypertensive therapy may be achieved by practical moderate sodium restriction.
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References
Morgan T, Gillies A, Morgan G, Adam W, Wilson M, Carney S (1978) Hypertension treated by salt restriction. Lancet I:227–30
Morgan T, Myers J, Carney S (1979) The evidence that salt is an important aetiological agent, if not the cause, of hypertension. Clin Sci 57:459s-62
Morgan TO, Myers JB (1981) Hypertension treated by sodium restriction. Med J Aust 2:396–97
MacGregor GA, Best FE, Cam JM, Markandu NM, Elder DM, Sagnella GA, Squires M (1982) Double-blind randomised crossover trial of moderate sodium restriction in essential hypertension. Lancet I:351–55
Meneely GR, Battarbee HD (1976) High sodium-low potassium environment and hypertension. Am J Cardiol 38:768–85
Skrabal F, Auböck J, Hörtnagl H (1981) Low sodium/high potassium diet for prevention of hypertension: probable mechanism of action. Lancet II:895–900
Burstyn P, Hornall D, Watchorn C (1980) Sodium and potassium intake and blood pressure. Br Med J 281:537–39
Liddle GW, Bennett LL, Forsham PH (1953) The prevention of ACTH-induced sodium retention by the use of potassium salts: a quantitative study. J Clin Invest 32:1197–201
Dahl LK, Leitl G, Heine M (1972) Influence of dietary potassium and sodium/potassium molar ratios on the development of salt hypertension. J Exp Med 136:318–28
Kawasaki T, Delea CS, Bartter FC, Smith H (1978) The effect of high-sodium and low-sodium intakes on blood pressure and other related variables in human subjects with idiopathic hypertension. Am J Med 64:193–8
Fujita T, Henry WL, Bartter FC, Lake CR, Delea CS (1980) Factors influencing blood pressure in salt-sensitive patients with hypertension. Am J Med 69:334–44
MacGregor GA, Smith SJ, Markandu ND, Banks RA, Sagnella GA (1982) Moderate potassium supplementation in essential hypertension. Lancet 2:567–70.
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This work was supported by the “Fonds zur Förderung der wissenschaftlichen Forschung” and by the “Jubiläumsfonds der Nationalbank” Austria
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Skrabal, F., Gasser, R.W., Finkenstedt, G. et al. Low-sodium diet versus low-sodium/high-potassium diet for treatment of hypertension. Klin Wochenschr 62, 124–128 (1984). https://doi.org/10.1007/BF01738702
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DOI: https://doi.org/10.1007/BF01738702