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Tumor-immunotherapy with the use of tumor-antigen-pulsed antigen-presenting cells

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Summary

Our previous study demonstrated that the administration of antigen-presenting cells (APC) pulsed with tumor cell membrane fraction to naive syngeneic mice results in effective induction of tumor-specific protective immunity in vivo. The present study examined whether tumor-antigen-pulsed APC can produce the inhibitory effect on the growth of tumor cells when administered to tumor-bearing hosts. Naive BALB/c mice were inoculated with viable tumor cells. Five days later, these mice started to receive the relevant tumor-antigen-pulsed APC at 3- to 4-day intervals. The administration of tumor-antigenpulsed APC induced the rejection or growth inhibition of a growing tumor in approximately half of the recipient mice. Moreover, it was demonstrated that tumor-specific immunity was induced in such tumor-regressed mice. These results indicate that tumor-antigen-pulsed APC are effectively applicable to the tumor-specific immunotherapy.

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Authors and Affiliations

  1. Biomedical Research Center, Osaka University Medical School, 2-2, Yamadaoka, 565, Suita, Osaka, Japan

    Jian-ping Zou, Jun Shimizu, Kazuhiro Ikegame, Hidekazu Takiuchi, Hiromi Fujiwara & Toshiyuki Hamaoka

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  1. Jian-ping Zou
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  2. Jun Shimizu
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  3. Kazuhiro Ikegame
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  4. Hidekazu Takiuchi
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  5. Hiromi Fujiwara
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  6. Toshiyuki Hamaoka
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This work was supported by Special Project Research-Cancer Bioscience from the Ministry of Education, Science and Culture, Japan

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Zou, Jp., Shimizu, J., Ikegame, K. et al. Tumor-immunotherapy with the use of tumor-antigen-pulsed antigen-presenting cells. Cancer Immunol Immunother 35, 1–6 (1992). https://doi.org/10.1007/BF01741047

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  • DOI: https://doi.org/10.1007/BF01741047

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