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Multidisciplinary treatment for central nervous system tumours with nitrosourea compounds

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Summary

The authors report the results of a controlled clinical trial in patients with primitive and metastatic CNS tumours treated with combined therapy: surgery, radiotherapy, and chemotherapy (BCNU or CCNU). A total of 102 patients were treated, 50 with BCNU, and 52 with CCNU. The overall response (R. + P.R.) was 68% for the BCNU group, and 65% for the CCNU group. No significant differences were found between the two types of treatment, either in terms of response or in terms of quality and length of survival.

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Author notes

  1. P. Paoletti & R. Knerich

    Present address: Neurosurgical Clinic, University of Pavia, Italy

  2. G. Robustelli della Cuna & M. R. Strada

    Present address: Clinica del Lavoro Foundation, Division of Oncology, University of Pavia, Italy

Authors and Affiliations

    Authors
    1. P. Paoletti
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    2. G. Robustelli della Cuna
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    3. R. Knerich
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    4. M. R. Strada
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    Additional information

    This work was supported by the United States Public Health Service Grant No. 080090/4 from the National Institutes of Neurology and Blindness, Bethesda, U.S.A., and by the National Research Council, Rome, Italy.

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    Paoletti, P., Robustelli della Cuna, G., Knerich, R. et al. Multidisciplinary treatment for central nervous system tumours with nitrosourea compounds. Acta neurochir 41, 287–299 (1978). https://doi.org/10.1007/BF01811342

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