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Impaired local deiodination of thyroxine to triiodothyronine in dogs with symmetrical truncal alopecia

  • Biochemistry
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Abstract

Thyroid dysfunction causes certain dermatological alterations in dogs. Insufficient delivery of thyroid hormone to the skin may originate not only from inadequate thyroid function but also from impaired local activation of thyroxine in the target organ. Thyroid parameters and deiodination were investigated in healthy dogs (group C) and in dogs with cutaneous lesions associated with hypothyroidism (group H) or with a low-T3 syndrome (group LT). The ability of the skin to convert T4 to T3 was impaired in both groups H and LT but not in the controls. It is concluded that impaired local deiodination may contribute to skin problems in dogs.

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Abbreviations

bwt:

body weight

DTT:

dithiothreitol

PBS:

phosphate-buffered saline (pH 7.5, 0.05 mol/L)

PTU:

propylthiouracyl

RIA:

radioimmunoassay

TRH:

thyrotropin-releasing hormone

TSH:

thyroid-stimulating hormone

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Authors and Affiliations

  1. Department of Physiology and Biochemistry, University of Veterinary Science, Budapest, Pf.2, H-1400, Budapest, Hungary

    P. Rudas, T. Bartha & V. L. Frenyo

  2. Department of Surgery, University of Veterinary Science, Budapest, Pf.2, H-1400, Budapest, Hungary

    J. Toth

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  1. P. Rudas
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  2. T. Bartha
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  3. J. Toth
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  4. V. L. Frenyo
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Rudas, P., Bartha, T., Toth, J. et al. Impaired local deiodination of thyroxine to triiodothyronine in dogs with symmetrical truncal alopecia. Vet Res Commun 18, 175–182 (1994). https://doi.org/10.1007/BF01839266

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  • DOI: https://doi.org/10.1007/BF01839266

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