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Physicochemical characterization of cholesterol-beta cyclodextrin inclusion complexes

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Abstract

Study and characterization of molecular complexes between cholesterol and beta cyclodextrin has been done using X-ray diffraction, thermogravimetric analysis (TG), differential scanning calorimetry (DSC) and nuclear magnetic resonance spectroscopy (13C NMR). Whatever the value of the molar ratio cholesterol/βCD used during the preparation, the same compound is always obtained. Corresponding to a molar ratio 1/3 (cholesterol/βCD), this compound is a stable hydrate which, contrary toβCD, contains at room temperature a large amount of molecules of water. It can be dehydrated under low pressure but the thermal degradation occurs at 200°C (250°C forβCD). This implies that cholesterol is strongly bounded toβCD.

Zusammenfassung

Mittels Röntgendiffraktion, TG, DSC und13C-NMR-Spektroskopie wurden Molekülkomplexe zwischen Cholesterol und Betacyclodextrin untersucht und charakterisiert. Unabhängig von dem bei der Herstellung angewendeten Cholesterol/ßCD-Verhältnis wurde immer die gleiche Verbindung erhalten. Bei einem Molverhältnis 1/3 (Cholesterol/BCD) ist diese Verbindung ein stabiles Hydrat, das im Gegensatz zu ßCD bei Raumtemperatur eine große Anzahl von Wassermolekülen enthält. Es kann in Vakuum dehydratiert werden, die thermische Zersetzung erfolgt bei 200°C (250°C für ßCD). Dies setzt voraus, daß Cholesterol fest an ßCD gebunden ist.

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Authors and Affiliations

  1. Laboratoire de Thermochimie Minérale (URA 116) INSA, 69621, Villeurbanne, Cedex, France

    P. Cloudy, J. M. Létoffé, P. Germain, J. P. Bastide, A. Bayol, S. Blasquez, R. C. Rao & B. Gonzalez

  2. Sanofi Elf Bio Recherches Centre de Labège Innopole, BP 137 31328, Labège, Cedex, France

    A. Bayol & S. Blasquez

  3. Sanofi Recherches 195 Rte D'espagne, 31036, Toulouse, France

    R. C. Rao & B. Gonzalez

Authors
  1. P. Cloudy
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  2. J. M. Létoffé
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  3. P. Germain
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  4. J. P. Bastide
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  5. A. Bayol
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  6. S. Blasquez
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  7. R. C. Rao
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  8. B. Gonzalez
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Cloudy, P., Létoffé, J.M., Germain, P. et al. Physicochemical characterization of cholesterol-beta cyclodextrin inclusion complexes. Journal of Thermal Analysis 37, 2497–2506 (1991). https://doi.org/10.1007/BF01912796

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  • DOI: https://doi.org/10.1007/BF01912796

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