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Fifty years of amanitin

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Abstract

Pharmacokinetic studies have provided new insights into humanAmanita poisoning, but it appears to be impossible to treat this intoxication by immunotherapy. New synthetic analogs have revealed structure-activity relationships that were unknown so far. The main toxin, α-amanitin, is in constant use as a tool in molecular biology and in biological research. First experiments have been reported in which amanitin bound to polymers could be internalized into tumor cells via a receptor-mediated endocytosis.

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  1. Max-Planck-Institut für Medizinische Forschung, Jahnstr. 29, D-6900, Heidelberg, Germany

    T. Wienland & H. Faulstich

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Wienland, T., Faulstich, H. Fifty years of amanitin. Experientia 47, 1186–1193 (1991). https://doi.org/10.1007/BF01918382

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