Abstract
Intracellular calcium concentration is a sensitive marker of the homeostasis of living cells, and its increase is an essential step of T lymphocyte activation. Changes in the environment provoke an adaptive stress-response of the organism. In our present work we have investigated the effect of chronic overcrowding on resting and lectin-stimulated cytoplasmic free calcium concentration of splenic T lymphocytes from young and aged CBA/CA mice (50 animals total). The animals were kept under ‘normal’ (68 cm2/animal) or ‘overcrowded’ (22 cm2/animal) conditions for 3 months. Young animals showed no change in resting and stimulated calcium after overcrowding. T cells from aged mice, however, displayed significantly smaller levels of both resting and lectin-stimulated intracellular calcium concentration (p<0.01 each), as compared to those of the non-stressed, aged animals. This inadequate adaptation in the calcium metabolism of T lymphocytes may significantly contribute to the diminished immune response of the aged in stress.
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Csermely, P., Pénzes, I. & Toth, S. Chronic overcrowding decreases cytoplasmic free calcium levels in T lymphocytes of aged CBA/CA mice. Experientia 51, 976–979 (1995). https://doi.org/10.1007/BF01921751
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DOI: https://doi.org/10.1007/BF01921751