Zusammenfassung
Telecinobufagin (I) wurde in Marinobufagin (IVa) und in Marinobufotoxin (V) übergeführt. Hauptreaktionsschritte: Umsetzung des Olefins II zum Halohydrin III mit anschliessender Epoxydierung (III→IVa). Das so erhaltene Marinobufagin (IVa) wurde mit Arginin-monohydrochlorid unter Verwendung der MCA-Technik zu Marinobufotoxin (V) kondensiert.
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References
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We are indebted to ProfessorK. Meyer for providing the natural specimen.
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Dedicatded to Prof.H. Ruschig on the occasion of his 65th birthday.
This investigation was supported by Public Health Service Research Grants No. 5 RO1 CA 11451-03 and No. 2 RO1 CA 10612-04 from the National Cancer Institute and represents Part 22 of the series Bufadienolides. For the preceding contribution refer to:G. R. Pettit andY. Kamano, J. org. Chem.37, in press (1972).
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Kamano, Y., Pettit, G.R. Synthesis of marinobufagin and marinobufotoxin from telecinobufagin. Experientia 28, 768 (1972). https://doi.org/10.1007/BF01923116
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DOI: https://doi.org/10.1007/BF01923116