Abstract
Adenosine 5′-triphosphate (ATP) was released into the perfusate of rat isolated mesenteric arterial beds during each of two consecutive increases in flow. There was no significant difference between the amounts of ATP released on each occasion. Substance P was also released into the perfusate by increased flow, although its release was more variable. Removal of the endothelium of the mesenteric vessels with sodium deoxycholate led to a significant reduction (74%) in the amount of ATP released compared with the release before the endothelium had been removed. This suggests that the ATP released into the mesenteric arterial perfusate during increased flow arises from endothelial cells.
Similar content being viewed by others
References
Kawasaki, H., Takasaki, K., Saito, A. and Goto, K., Nature335 (1988) 164.
Furchgott, R. F. and Zawadski, J. V., Nature288 (1980) 373.
Furchgott, R. F., Circ. Res.53 (1983) 557.
Smiesko, V., Kozik, J., and Dolezel, S., Blood Vessels22 (1985) 247.
Holtz, J., Forstermann, U., Pohl, U., Giesler, M., and Bassenge, E., J. cardiovasc. Pharmac.6 (1984) 1161.
Rubanyi, G. M., Romero, J. C., and Vanhoutte, P. M., Am. J. Physiol.250 (1986) H1145.
Kaiser, L., Hull, S. S., and Sparks, H. V. Jr, Am. J. Physiol.250 (1986) H974.
Hull, S. S., Kaiser, L., Jaffe, M. D., and Sparks, H. V., Blood Vessels23 (1986) 183.
Griffith, T. M., Edwards, D. H., Davies, R. L., Harrison, T. J., and Evans, K. T., Nature329 (1988) 442.
Smiesko, V., Lang, D. J., and Johnson, P. C., Fedn Proc.46 (1987) 643.
Peach M. J., Loeb, A. L., Singer, H. A., and Saye, J., Hypertension, suppl. I,7 (1985) I94.
Vanhoutte, P. M., Rubanyi, G. M., Miller, V. M., and Houston, D. S., Ann. Rev. Physiol.48 (1986) 307.
Burnstock, G., Lincoln, J., Fehér, E., Hopwood, A. M., Kirkpatrick, K., Milner, P., and Ralevic, V. Experientia44 (1988) 705.
Linnik, M. D., and Moskowitz, M. A. Peptides10 (1989) 957.
Ralevic, V., Lincoln, J., and Burnstock, G., in: Endothelial Regulation of Vascular Tone. Eds U. S. Ryan and G. M. Rubanyi. Marcel Dekker, New York 1990.
Parnavelas J. G., Kelly, W., and Burnstock, G., Nature316 (1985) 724
Loesch, A., and Burnstock, G., Anat. Embryol. (Berl.)178 (1988) 137.
Milner, P., Ralevic, V., Hopwood, A. M., Fehér, E., Lincoln, J., Kirkpatrick, K. A., and Burnstock, G., Experientia45 (1989) 121.
Lincoln, J., Loesch, A., and Burnstock, G., Cell Tissue Res.259 (1990) 341.
Ralevic, V., Milner, P., Hudlická, O., Kristek, F., and Burnstock, G., Circ. Res.66 (1990) 1178.
Milner, P., Kirkpatrick, K. A., Ralevic, V., Toothill, V., Pearson, J. D., and Burnstock, G., Proc. Roy. Soc. B241 (1990) 245.
Milner P., Bodin, P., Loesch, A., and Burnstock, G., Biochem. biophys. Res. Commun.170 (1990) 649.
Ralevic, V., and Burnstock, G., Br. J. Pharmac.95 (1988) 637.
Kirkpatrick, K., and Burnstock, G., Eur. J. Pharmac.138 (1987) 207.
Burnstock, G., Pharmac. Rev.24 (1972) 509.
Burnstock, G., Trends Pharmac. Sci.9 (1988) 116.
Gordon, J. L., Biochem. J.233 (1986), 309.
Rapaport, E., and Fontaine, J., Proc. natl Acad. Sci. USA86 (1989) 1662.
Pearson, J. D., and Gordon, J. L., Nature281 (1979) 384.
Rubanyi, G. M., Romero, J. C., and Vanhoutte, P. M., Am. J. Physiol.250 (1986) H1145.
Bevan, J. A., and Joyce, E. H., Blood Vessels25 (1988) 101.
Bodin, P., Bailey, D. J., and Burnstock, G., Br. J. Pharmac.103 (1991) 1203.
Scott, T. M., Robinson, J., and Foote, J., J. Anat.162 (1989) 177.
Hopwood, A. M., Lincoln, J., Kirkpatrick, K. A., and Burnstock, G., Eur. J. Pharmac.165 (1989) 323.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ralevic, V., Milner, P., Kirkpatrick, K.A. et al. Flow-induced release of adenosine 5′-triphosphate from endothelial cells of the rat mesenteric arterial bed. Experientia 48, 31–34 (1992). https://doi.org/10.1007/BF01923600
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01923600