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Ambivalent effect of protein binding on computed distributions of metal ions complexed by ligands in blood plasma

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  • Chimica, Biochimica
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Summary

Although the absolute concentrations of metal complexes in blood plasma are controlled by protein binding, the percentage distribution of transition metal ions amongst low molecular weight ligands is not. Thus, computer simulations which omit protein equilibria can nevertheless afford reliable information about such metals in the biofluid.

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Authors and Affiliations

  1. Department of Physical Chemistry, University of Cape Town, Rondebosch, Cape, Republic of South Africa

    P. M. May, P. W. Linder & D. R. Williams

  2. Department of Chemistry, University of St. Andrews, KY16 9ST, St. Andrews, Scotland

    P. M. May, P. W. Linder & D. R. Williams

Authors
  1. P. M. May
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  2. P. W. Linder
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  3. D. R. Williams
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Additional information

Acknowledgments. One of us (P. M. M.) thanks the University of Cape Town and the C. S. I. R. for financial assistance. Computations were performed on both of the University of Cape Town's UNIVAC 1106 system and the St. Andrews University's IBM 360/44. Address ofP. W. Linder: University of Cape Town, Rondebosch, Cape (South Africa).

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May, P.M., Linder, P.W. & Williams, D.R. Ambivalent effect of protein binding on computed distributions of metal ions complexed by ligands in blood plasma. Experientia 32, 1492–1494 (1976). https://doi.org/10.1007/BF01924411

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  • DOI: https://doi.org/10.1007/BF01924411

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