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Synthesis of Eel-Calcitonin and [Asu1,7]-Eel-Calcitonin: Contribution of the disulfide bond to the hormonal activity

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  • Chimica, Biochimica
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Summary

Eel-calcitonin and its [Asu1,7]-analog, deamino-dicarba-analog, were synthesized by the conventional solution method. The natural-type product showed 4300 MRC U/mg in the hypocalcemic potency which was comparable to that of the natural hormone isolated from eel. Hormonal activity of the Asu-analog was also as high as 3400 MRC U/mg.

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Authors and Affiliations

  1. Peptide Institute, Protein Research Foundation, 476 Ina, 562, Minoh, Osaka, (Japan)

    T. Morikawa, E. Munekata & S. Sakakibara

  2. Research Laboratory, Toyo Jozo Co., Ltd., 410-23, Ohilo, Shizuoka, (Japan)

    T. Noda & M. Otani

Authors
  1. T. Morikawa
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  2. E. Munekata
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  3. S. Sakakibara
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  4. T. Noda
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  5. M. Otani
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Morikawa, T., Munekata, E., Sakakibara, S. et al. Synthesis of Eel-Calcitonin and [Asu1,7]-Eel-Calcitonin: Contribution of the disulfide bond to the hormonal activity. Experientia 32, 1104–1106 (1976). https://doi.org/10.1007/BF01927568

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  • DOI: https://doi.org/10.1007/BF01927568

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