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Occurrence of trichochromes in the urine of a melanoma patient

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  • Chimica, Biochimica
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Summary

The presence of two phaeomelanic pigments, trichochrome B and C, was demonstrated in the urine of a patient with malignant melanoma metastases.

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References

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  10. Decarboxytrichochrome C was also obtained simply by oxidation of 5-S-cysteinyldopa in 0.1N NaOH with atmospheric oxygen for a few minutes, follwed by acidification and boiling of the reaction mixture.

  11. Work at our laboratory has demonstrated the presence of large amounts of 2-S-cysteinyldopa in the urines of melanoma patients.

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Authors and Affiliations

  1. Department of Organic Chemistry, University of Naples, Napoli, (Italy)

    G. Prota, H. Rorsman, A. -M. Rosengren & E. Rosengren

  2. Department of Dermatology, Biochemistry and Pharmacology, University of Lund, S-221 85, Lund, (Sweden)

    G. Prota, H. Rorsman, A. -M. Rosengren & E. Rosengren

Authors
  1. G. Prota
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  2. H. Rorsman
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  3. A. -M. Rosengren
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  4. E. Rosengren
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Additional information

Supported by grants from the Swedish Cancer Society (No. 626-B75-04XA), 869-B75-01P, the Swedish Medical Research Council (No. B76-04X-00056-12), and the Walter, Ellen and Lennart Hesselman Foundation for Scientific Research. ProfessorProta was a visiting scientist of the Swedish Cancer Society (No. 626-B75-04U).

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Prota, G., Rorsman, H., Rosengren, A.M. et al. Occurrence of trichochromes in the urine of a melanoma patient. Experientia 32, 1122–1124 (1976). https://doi.org/10.1007/BF01927580

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  • DOI: https://doi.org/10.1007/BF01927580

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