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Stable lipid peroxidation products in human skin: detection, ultraviolet light-induced increase, pathogenic importance

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Summary

Products of lipid peroxidation (malonaldehyde, Schiff-bases) were detected in human skin. These products were increased after UV-light exposition, on chronically sun-exposed areas as well as with advancing age. Malonaldehyde cross linked epidermal glucose-6-phosphate-dehydrogenase and diminished their activity.

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Authors and Affiliations

  1. Bereich medizin (Charité) der Humboldt-Universität zu Berlin, Haut- und Poliklinik, Schumannstrasse 20-21, DDR-104, Berlin, Germany

    H. Meffert, W. Diezel & N. Sönnichsen

Authors
  1. H. Meffert
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  2. W. Diezel
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  3. N. Sönnichsen
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Additional information

We wish to acknowledge the support and encourgement of Dr.W. E. Höhne, Institute of Physiological and Biological Chemistry, Humboldt University Berlin.

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Meffert, H., Diezel, W. & Sönnichsen, N. Stable lipid peroxidation products in human skin: detection, ultraviolet light-induced increase, pathogenic importance. Experientia 32, 1397–1398 (1976). https://doi.org/10.1007/BF01937397

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  • DOI: https://doi.org/10.1007/BF01937397

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