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The action of substance P on mesencephalic reticular and substantia nigral neurones of the rat

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Summary

Extracellular recordings were made from neurones in the mesencephalic reticular formation and substantia nigra of the rat which was anaesthetized with urethane 1.5–2 g/kg i.p. Out of 44 cells tested 42 were excited by Substance P applied iontophoretically and in some cases this excitation was rapid. Evidence is presented for Substance P as a putative excitatory transmitter onto reticular and nigral neurones possibly released from primary sensory afferents.

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Authors and Affiliations

  1. Department of Physiology and Biochemistry, University of Southampton, S09 5NH, Southampton, England

    R. J. Walker, J. A. Kemp, K. Kitagawa & G. N. woodruff

  2. Faculty of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan

    R. J. Walker, J. A. Kemp, H. Yajima, K. Kitagawa & G. N. woodruff

Authors
  1. R. J. Walker
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  2. J. A. Kemp
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  3. H. Yajima
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  4. K. Kitagawa
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  5. G. N. woodruff
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Walker, R.J., Kemp, J.A., Yajima, H. et al. The action of substance P on mesencephalic reticular and substantia nigral neurones of the rat. Experientia 32, 214–215 (1976). https://doi.org/10.1007/BF01937772

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