Skip to main content
SpringerLink
Log in

Identification of norcocaine as a metabolite of [3H]-cocaine in rat brain

  • Pharmacologica
  • Published:
Experientia Aims and scope Submit manuscript

Zusammenfassung

Nach. s.c. und i.v. Injektionen von Cocain in Ratten wurde Cocain im Hirn rasch metabolisiert. Ausser Benzoylecgonin, Benzoylnorecgnin und Ecgonin wurde Norcocazin als wichtiger Metabolit identifiziert.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. A. L. Tatum andM. H. Seevers, J. Pharmac. exp. Ther.36, 401 (1929).

    CAS  Google Scholar 

  2. G. A. Deneau, T. Yanagita andM. H. Seevers, Psychopharmacologia,16, 30 (1969).

    Article  CAS  Google Scholar 

  3. H. A. Oelkers andW. Raetz, Arch. exp. Path. Pharmak.170, 246 (1933).

    Article  CAS  Google Scholar 

  4. H. A. Oelkers andE. Vincre, Arch. exp. Path. Pharmak.179, 341 (1935).

    Article  CAS  Google Scholar 

  5. A. R. McIntyre, J. Pharmac. exp. Ther57, 133 (1936).

    Google Scholar 

  6. L. A. Woods, F. G. McMahon andM. H. Seevers, J. Pharmac. esp. Ther.101, 200 (1951).

    CAS  Google Scholar 

  7. R. V. Ortiz, Annis Fac. Quim. Farm. (Chile)18, 15 (1966).

    Google Scholar 

  8. G. Werner, Planta med.9, 293 (1961).

    Article  CAS  Google Scholar 

  9. J. M. van Rossum, J. B. van Der Schoot andJ. A. Th. M. Hurkmans, Experientia18, 229 (1962).

    Article  CAS  Google Scholar 

  10. F. Montesinos, Bull. Narcot.17, 11 (1965).

    Google Scholar 

  11. H. O. J. Collier, Nature, Lond.220, 1327 (1968).

    Article  CAS  Google Scholar 

  12. F. Fish andW. D. C. Wilson, J. Pharm. Pharmac.21, 135 S (1969).

    Article  CAS  Google Scholar 

  13. H. Langeker andK. Lewitt, Arch. exp. Path. Pharmak.190, 492 (1938).

    Article  Google Scholar 

  14. R. C. Hatch andR. Fischer, Pharmac Res. Commun.4, 383 (1972).

    Article  CAS  Google Scholar 

  15. P. K. Nayak, A. L. Misra, M. N. Patel andS. J. Mule, Radiochem. radionalyt. Lett.16, 167 (1974).

    CAS  Google Scholar 

  16. A. L. Misra andS. J. Mule', Nature, Lond.238, 155 (1972).

    Article  CAS  Google Scholar 

  17. A. L. Misra andS. J. Mule', Nature, Lond.241, 281 (1973).

    Article  CAS  Google Scholar 

  18. A. L. Misra, S. J. Mule', R. Bloch andN. L. Vadlamani, J. Pharmac. exp. Ther.185, 287 (1973).

    CAS  Google Scholar 

  19. A. L. Misra, R. B. Pontani andS. J. Mule', Xenobiotica4, 17 (1974).

    Article  CAS  Google Scholar 

  20. A. L. Misra, R. B. Pontani andS. J. Mule', J. Chromat.81, 167 (1973).

    Article  CAS  Google Scholar 

  21. H.-L. Schmidt andG. Werner, Liebigs Annln Chem.653 184 (1962).

    Article  CAS  Google Scholar 

  22. A. L. Misra, C. L. Mitchell andL. A. Woods, Nature, Lond.232, 48 (1971).

    Article  CAS  Google Scholar 

  23. E. G. Rozantsey andV. D. Sholle, Dokkl. Akad. Nauk. USSR187, 1319 (1969), chem. Abstr.71, 128619s (1973).

    Google Scholar 

  24. G. J. Giotta andH. H. Wang, Biochem. biophys. Res. Commun.46, 1576 (1972).

    Article  CAS  Google Scholar 

  25. A. L. Misra, R. B. Pontani andS. J. Mule', Experientia29, 1108 (1973).

    Article  CAS  Google Scholar 

  26. This work was supported by the U.S. Army Medical Research and Development Command under Research Contract No. DADA-17-73-c-3080.

Download references

Author information

Authors and Affiliations

  1. Testing and Research Laboratory, New York State Drug Abuse Control Commission, 80 Hanson Place, 11217, Brooklyn, New York, USA

    A. L. Misra, P. K. Nayak, M. N. Patel, N. L. Vadlamani & S. J. Mulé

Authors
  1. A. L. Misra
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. K. Nayak
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. N. Patel
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. L. Vadlamani
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. J. Mulé
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Misra, A.L., Nayak, P.K., Patel, M.N. et al. Identification of norcocaine as a metabolite of [3H]-cocaine in rat brain. Experientia 30, 1312–1314 (1974). https://doi.org/10.1007/BF01945203

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01945203

Keywords

Search

Navigation