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The effect of the phytoalexins, lubimin, (−)-maackiain, pinosylvin, and the related compounds dehydroloroglossol and hordatine M on human lymphoblastoid cell lines

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Summary

We have tested the effect of the phytoalexins lubimin, (−)-maackiain and pinosylvin and the related compounds dehydroloroglossol and hordatine M on the growth of the human lymphoblastoid cell lines Molt and Raji. (−)-maackiain, pinosylvin and dehydroloroglossol showed significant growth inhibitory action on the cells. Suppression of [3H] thymidine and [3H] leucine uptake was tested and noted in pinosylvin and dehydroloroglossol. The phytoalexins and related compounds are widespread in plants and provide a potential source of antineoplastic substances.

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Authors and Affiliations

  1. Department of Pathology, University of Saskatchewan, S7N OWO, Saskatoon, Saskatchewan, Canada

    L. Skinnider & A. Stoessl

  2. Research Centre, Agriculture Canada, University Sub Post Office, N6A 5B7, London, Ontario, Canada

    L. Skinnider & A. Stoessl

Authors
  1. L. Skinnider
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  2. A. Stoessl
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Additional information

We would like to acknowledge the assistance of J. Hux in preparing the phytoalexins and related compounds. This work was supported by a grant from National Health and Welfare Canada. Correspondence to Dr. L. Skinnider, Department of Pathology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7M OWO.

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Skinnider, L., Stoessl, A. The effect of the phytoalexins, lubimin, (−)-maackiain, pinosylvin, and the related compounds dehydroloroglossol and hordatine M on human lymphoblastoid cell lines. Experientia 42, 568–570 (1986). https://doi.org/10.1007/BF01946707

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