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Paracelsin, a peptide antibiotic containing α-aminoisobutyric acid, isolated fromTrichoderma ressei Simmons Part A

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Summary

A peptide antibiotic has been isolated fromTrichoderma reesei QM 9414. Although crystalline and unifiorm in TLC, this antibiotic could be resolved by HPLC into 3 sequence analoques. The close relationships to alamethicin was proved by chemical and spectroscopic methods, and the formation of ion-conducting prores in lipid bilayers.

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Literatur

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Authors and Affiliations

  1. Institut für Lebensmitteltechnologie, Universität Hohenheim, Garbenstrase 25, D-7000, Stuttgart-Hohenheim, Federal Republic of Germany

    H. Brückner & H. Graf

Authors
  1. H. Brückner
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  2. H. Graf
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Additional information

Part B of this piece of work has been submitted for publication in Experientia.

Acknowledgments. We thank Miss. I. Ackermann and Mrs A. Kaupp for their valuable technical assistance, Dr G. Wolf for supply with microorganisms, Mr H. Steingass for experiments on rumen fermentation, Dr M. Bokel for NMR and Prof. W. Christ for his encouragement.

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Brückner, H., Graf, H. Paracelsin, a peptide antibiotic containing α-aminoisobutyric acid, isolated fromTrichoderma ressei Simmons Part A. Experientia 39, 528–530 (1983). https://doi.org/10.1007/BF01965190

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  • DOI: https://doi.org/10.1007/BF01965190

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