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Effect of particle size of dried mycobacteria on adjuvant induced arthritis in the rat

  • Immunosuppression and Inflammation
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Abstract

Freund's complete adjuvant prepared by grinding dried, heat killedMycobacterium tuberculosis with liquid paraffin was investigated for particle size-weight distribution. Variations in the grinding times and preparative procedure had a marked effect on the arthritogenic action of the adjuvant in the rat. A satisfactory response in the injected foot was found only when the particle size was less than 19 μm and a secondary response in the non-injected foot required particles less than 10 μm in diameter.

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Authors and Affiliations

  1. Pharmacological Laboratories, Department of Pharmacy, University of Aston in Birmingham, Gosta Green, B4 7ET, Birmingham, UK

    R. Best, R. Christian & D. A. Lewis

Authors
  1. R. Best
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  2. R. Christian
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  3. D. A. Lewis
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Best, R., Christian, R. & Lewis, D.A. Effect of particle size of dried mycobacteria on adjuvant induced arthritis in the rat. Agents and Actions 14, 265–268 (1984). https://doi.org/10.1007/BF01966651

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  • DOI: https://doi.org/10.1007/BF01966651

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