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Renal injury after muscle extract infusion in rats: Absence of toxicity with myoglobin

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Summary

A crude muscle extract infused into rats produced oliguria, a precipitous drop in total hemolytic complement, and in circulating white cell and platelets counts. A mild vaso-depressor effects was noted. These changes were not produced by myoglobin or saline infusion. Muscle constituents other than myoglobin are responsible for the systemic and renal nephrotoxic effects observed.

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Authors and Affiliations

  1. Department of Nephrology, McGill University, Montreal Children's Hospital Research Institute, 2300 Tupper Street, B3H 1P3, Montreal, Quebec, Canada

    S. O'Regan, J. S. C. Fong & K. N. Drummond

Authors
  1. S. O'Regan
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  2. J. S. C. Fong
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  3. K. N. Drummond
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Supported by Medical Research Council of Canada grant MA-1579.

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O'Regan, S., Fong, J.S.C. & Drummond, K.N. Renal injury after muscle extract infusion in rats: Absence of toxicity with myoglobin. Experientia 35, 805–806 (1979). https://doi.org/10.1007/BF01968262

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  • DOI: https://doi.org/10.1007/BF01968262

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