Skip to main content
SpringerLink
Log in

Clinical pharmacology of GP53,633—a new non-steroidal anti-inflammatory drug — in patients with rheumatoid arthritis

  • Immunosuppression and Inflammation
  • Review
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

GP53,633 is a new basic non-steroidal anti-inflammatory drug showing analgesic and anti-inflammatory activity in animal models. Pharmacokinetic studies in 6 patients with rheumatoid arthritis show it to be rapidly absorbed with a short half life (approximately 2 hours). No change in pharmacokinetics is seen over a two week treatment period. Clinical parameters of inflammation were reduced and no adverse reactions were seen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S. Wanwimolruk, D.J. Birkett andP.M. Brooks,Protein binding of GP53,633: a basic non-steroidal anti-inflammatory drug, Biochem. Pharmac.31, 3737 (1982).

    Google Scholar 

  2. M.W. Ropes, G.A. Bennett, S. Cobb, R. Jacox andR.A. Jessar,Revision of diagnostic criteria for rheumatoid arthritis, Ann. rheum. Dis.18, 49–53 (1959).

    Google Scholar 

  3. P.M. Ritchie, J.A. Boyle, J.M. McInnes, M.K. Jasani, T.G. Dalakos, P. Grieveson andW.W. Buchanan,Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis, Q. Jl.Med.37, 393–406 (1968).

    Google Scholar 

  4. E.H. Wiseman andJ.A. Boyle,Piroxicam (Feldene), Clin. rheum. Dis.6, 585–613 (1980).

    Google Scholar 

  5. E.C. Huskisson, P.L. Woolf, H.W. Balme, J. Scott andS. Franklyn,Four new anti-inflammatory drugs: Responses and variations, Br. med. J.1, 1048–1049 (1976).

    Google Scholar 

  6. E.P. Gall, E.M. Caperton andJ.E. McComb,Clinical comparison of Ibuprofen, Fenoprofen, Calcium and Tolmetin sodium in rheumatoid arthritis, J. Rheum.9, 402–407 (1982).

    Google Scholar 

  7. E.C. Huskisson, P.A. Dieppe, J. Scott andH. Jones,Diclofenac Sodium, Diflunisal and Naproxen: Patients preferences for anti-inflammatory drugs in rheumatoid arthritis, Rheum. Rehab.21, 238–242 (1982).

    Google Scholar 

Download references

Author information

Author notes

  1. S. Wanwimolruk

    Present address: Department of Pharmacology, Prince of Songkla University, Haad-Yai, Thailand

Authors and Affiliations

  1. Department of Medicine, The Flinders University of South Australia, 5042, Adelaide, S.A., Australia

    D. Thomas & P. M. Brooks

  2. Clinical Pharmacology, The Flinders University of South Australia, 5042, Adelaide, S.A., Australia

    S. Wanwimolruk, D. J. Birkett & J. O. Miners

Authors
  1. S. Wanwimolruk
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Thomas
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. J. Birkett
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. O. Miners
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. M. Brooks
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wanwimolruk, S., Thomas, D., Birkett, D.J. et al. Clinical pharmacology of GP53,633—a new non-steroidal anti-inflammatory drug — in patients with rheumatoid arthritis. Agents and Actions 15, 424–427 (1984). https://doi.org/10.1007/BF01972382

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01972382

Keywords

Search

Navigation