Summary
Intraperitoneal and intraventricular injection of histamine induces a very fast and high elevation of vasopressin in rat plasma as determined by radioimmunoassay. The effects are dose and time related. The intraventricular injection is more effective with regard to time and dose than the intraperitoneal injection.
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References
S. H. Snyder andK. M. Taylor, inPerspectives in Neuropharmacology (Ed.S. H. Snyder; Oxford University Press, New York 1972), p. 43.
K. M. Taylor, E. Gfeller andS. H. Snyder, Brain Res.41, 171 (1972).
C. T. Bennett andA. Pert, Brain Res.78, 151 (1974).
H. L. Haas, P. Wolf andJ.-C. Nussbaumer, Brain Res.88, 166 (1975).
M. C. Gerald andR. P. Maickel, Br. J. Pharmac.44, 462 (1972).
Tj. B. van Wimersma Greidanus, R. M. Buys, H. J. G. Hollemans andW. de Jong, Experientia30, 1217 (1974).
J. Dogterom, R. M. Buys andTj. B. van Wimersma Greidanus, in preparation.
H. Valtin, W. H. Sawyer andH. W. Sokol, Endocrinology77, 701 (1965).
K. P. Bhargava, V. K. Kulshrestha, G. Santhakumari andY. P. Srivastava, Br. J. Pharmac.47, 700 (1973).
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Dogterom, J., van Wimersma Greidanus, T.B. & De Wied, D. Histamine as an extremely potent releaser of vasopressin in the rat. Experientia 32, 659–660 (1976). https://doi.org/10.1007/BF01990220
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DOI: https://doi.org/10.1007/BF01990220