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Epidermal growth factor enhancement of skin tumor induction in mice

  • Specialia
  • Anatomica, Histologica, Embryologica, Carcinologica
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Summary

Subcutaneous injection of epidermal growth factor 1. significantly shortened the latency period for the appearance of methylcholanthrene induced skin tumors and 2. increased the average number of papillomas elicited per mouse in both the Swiss Webster and C3HeB/FeJ strains.

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Authors and Affiliations

  1. Department of Biological Chemistry and Laboratory of Nuclear Medicine and Radiation Biology, UCLA School of Medicine, 90024, Los Angeles, California, USA

    S. P. Rose, R. Stahn, D. S. Passovoy & H. Herschman

Authors
  1. S. P. Rose
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  2. R. Stahn
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  3. D. S. Passovoy
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  4. H. Herschman
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Additional information

Acknowledgments. This research was supported by USPHS NCI Grant No. CA 15276 and Contract No. GEN-12 between the Regents of the University of California and the U.S. Energy Research and Development Administration. We thankIlmar Lepik for his assistance in some phases of these experiments.

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Rose, S.P., Stahn, R., Passovoy, D.S. et al. Epidermal growth factor enhancement of skin tumor induction in mice. Experientia 32, 913–915 (1976). https://doi.org/10.1007/BF02003764

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  • DOI: https://doi.org/10.1007/BF02003764

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