Summary
The intrinsic viscosity of hyaluronic acid in synovial fluid decreases significatively in mild and severe arthritis (24% and 37% respectively). Variation in hyaluronic acid concentration parallels the above results. Chondroitin-6-sulfate can be detected in about 30% of the arthritic fluids.
Similar content being viewed by others
References
J.E. Smith and G.T. Crowlwy, J. Arthritis Rheum.3, 409 (1960).
J. Sandson, Science155, 839 (1967).
J.A. Kofoed, A.A. Tocci and A.C. Barceló, Experientia29, 680 (1973).
Committee of American Rheumatic Association, Arthritis Rheum.2, 16 (1959).
E.A. Balasz, D. Warson, I.F. Duff and S. Roseman, Arthritis Rheum.10, 357 (1957).
L. Sundblad, Acta soc. Med. upsal.58, 113 (1953).
T. Bitter and H.M. Muir, Analyt. Biochem.4, 330 (1962).
C.A. Antonopoulos and S. Gardell, Acta chem. scand.17, 1474 (1963).
K. Murata, T. Harada, T. Fujiwara and T. Furuhashi, Biochim. biophys. Acta230, 583 (1971).
A.J. Bollet, J. Lab. clin. Med.48, 721 (1956).
M.G. Levine and D.H. Kling, J. clin. Invest.35, 1419 (1956).
E.A. Balasz and I.F. Duff, in: The Amino Sugars, vol. 2A, p. 237. Ed. E.A. Balasz and R.W. Jeanloz, Academic Press, New York 1965.
R. Eckholm and B. Nordback, Acta orthop. scand.21, 81 (1951).
Author information
Authors and Affiliations
Additional information
This work was partially supported by the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina.
Rights and permissions
About this article
Cite this article
Kofoed, J.A., Barceló, A.C. The synovial fluid hyaluronic acid in rheumatoid arthritis. Experientia 34, 1545–1546 (1978). https://doi.org/10.1007/BF02034662
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02034662