Abstract
The paper describes studies of the influence of a number of genetically-mapped auxotrophic mutations on the virulence ofAspergillus nidulans for DBA/2J male mice. Specific mutations were found to be either neutral in regard to the character of virulence, i.e., strains carrying such mutations had a virulence similar to that of prototrophic strains, or were associated with significantly decreased virulence or avirulence. These data provide the first extensive information concerning the effects of auxotrophic mutation on the virulence of a mycotic pathogen of animals.
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Purnell, D.M. The effects of specific auxotrophic mutations on the virulence of Aspergillus nidulans for mice. Mycopathologia et Mycologia Applicata 50, 195–203 (1973). https://doi.org/10.1007/BF02053368
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DOI: https://doi.org/10.1007/BF02053368