Abstract
The following study on natural immunology in schizophrenic patients aims at elucidating differential effects of psychopathological status and neuroleptic treatment. Natural killer (NK-) cell activity and antibody dependent cellular cytotoxity (ADCC) were tested in 24 adolescent schizophrenic patients and compared to 27 adult schizophrenics and healthy controls. Twelve adolescent patients were tested before and after 2 weeks on neuroleptic treatment. Age or psychopathological status did not have a significant impact on NK-activity or ADCC. There were no significant general effects resulting from neuroleptic treatment on NK-activity detectable in patients tested before and during treatment. However, there was a significant negative correlation between the differences of NK-activity (before and during treatment) and the NK-activity before treatment.
Résumé
L'étude suivante sur l'immunologie naturelle chez les patients schizophrènes a pour but d'élucider les effets différentiels de l'état psychopathologique et des “Natural Killer” (NK) et la cytotoxicité cellulaire anti-corps dépendant (ADCC) furent testés chez 24 adolescents schizophrènes et comparés à 27 adultes schizophrènes ainsi qu'à un groupe de contrôle. 12 patients adolescents furent testés avant et après 2 semaines de traitement neuroleptique. L'âge et le statut psychopathologique n'avaient pas d'impact significatif sur NK-activité ou l'ADCC. Il n'y a eu aucun effet significatif en général résultant d'un traitement neuroleptique sur NK-activité détectable chez des patients testés avant et pendant le traitement. Cependant il y eut une corrélation négative significative entre les différences de NK-activité (avant et pendant le traitement) et NK-activité avant le traitement.
Zusammenfassung
Die vorliegende Studie soll differentielle Effekte von Psychopathologie und neuroleptischer Medikation auf Parameter der Natural Killer-(NK)Zellfunktion untersuchen. 24 adoleszente und 27 erwachsene Patienten mit Psychosen aus dem schizophrenen Formenkreis wurden altersentsprechenden gesunden Kontrollgruppen gegenübergestellt. Als immunologische Testsysteme fungierten die “Natural Killer” (NK-)Aktivität und die “antibody dependent cellular cytotoxicity” (ADCC). 12 adoleszente Patienten wurden zweimal (vor und zwei Wochen nach Therapiebeginn mit Neuroleptika) immunologisch untersucht. Das Lebensalter und der psychopathologische Schweregrad zeigten keinen signifikanten Zusammenhang mit den immunologischen Daten. An den 12 Patienten mit Test-Retest-Design konnten keine unidirektionellen Effekte der Neuroleptikamedikation auf die Natural Killer-Zellfunktion statistisch nachgewiesen werden. Es fand sich aber eine signifikant negative Korrelation zwischen den Veränderungen der NK-Werte und den NK-Ausgangswerten vor Therapiebeginn. Dieser Zusammenhang wird im Lichte der Streß-Hypothese (einer differentiellen Beeinflussung des Immunsystems durch Streß und Coping) als möglicher Hinweis auf eine streßverringernde neuroleptische Wirkungskomponente diskutiert.
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Resch, F., Amminger, G.P., Aschauer, H. et al. Natural killer cell function in adolescent and adult schizophrenic patients. European Child & Adolescent Psychiatry 2, 155–160 (1993). https://doi.org/10.1007/BF02125570
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DOI: https://doi.org/10.1007/BF02125570