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Human pituitary growth hormone

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Zusammenfassung

Aus Tierexperimenten mit Wachstumshormonen aus Rindern wird klar, dass das Hormon eine Anzahl anderer biologischer Funktionen ausübt als seine wachstumsfördernde Tätigkeit. Im Menschen hat sich das Wachstumshormon als stärkstes anabolisches Agens der bisher untersuchten Arzneimittel oder Hormone erwiesen. Infolge der limitierten Hypophysenausscheidung blieben andere Merkmale der biologischen Förderung der Wachstumshormone für den gesunden wie auch den kranken Menschen unerforscht.

Beschränkte Hydrolyse mit Pepsin ergab, dass die Integrität des Wachstumshormonmoleküls nicht Voraussetzung für sein harmonisches Wirken ist. Hingegen ist es wahrscheinlich, dass ein Teil der 252 Aminosäurekette die biologischen Funktionen der Wachstumshormone bedingt. Die Kenntnis der vollständigen Primärstruktur des Wachstumsmoleküls würde die künstliche Herstellung einer entsprechenden Aminosäurefolge mit den biologischen Eigenschaften des Hormons ermöglichen.

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Authors and Affiliations

  1. Hormone Research Laboratory, University of California, Berkeley, California, U.S.A.

    Choh Hao Li & Wan-Kyng Liu

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  1. Choh Hao Li
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  2. Wan-Kyng Liu
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Additional information

Paper VIII of Human Pituitary Growth Hormone series. For Paper VII, seeC. H. Li, A. Tanaka, andB. T. Pickering, Acta Endocrinol., in press. Portions of this manuscript were abstracted from the Ph.D. thesis of W.K.L., September 1963. This work was supported in part by a grant from the American Cancer Society.

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Li, C.H., Liu, WK. Human pituitary growth hormone. Experientia 20, 169–178 (1964). https://doi.org/10.1007/BF02135393

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