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Comparative dominant lethal studies with phenylbutazone, thio-TEPA and MMS in the mouse

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  • Pharmacologica
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Zusammenfassung

Im Gegensatz zu Thio-TEPA (N, N′, N″-Triaethylen-thiophosphoramid) und MMS (Methansulfonsäuremethylester) führten i.p. Dosen von Phenylbutazon (50 und 100 mg/kg) bei der Maus, unter Berücksichtigung von post- und prae-implantativen Gestationsstadien, zu keinen genetischen Effekten im Sinne der Induktion von dominanten Letalfaktoren.

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Literatur

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Authors and Affiliations

  1. Biological Research Laboratories, Pharmaceutical Division of CIBA-GEIGY Limited, CH-4002, Basel, Switzerland

    L. Machemer & R. Hess

Authors
  1. L. Machemer
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  2. R. Hess
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Machemer, L., Hess, R. Comparative dominant lethal studies with phenylbutazone, thio-TEPA and MMS in the mouse. Experientia 27, 1050–1052 (1971). https://doi.org/10.1007/BF02138874

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  • DOI: https://doi.org/10.1007/BF02138874

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